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      Robust layer segmentation of esophageal OCT images based on graph search using edge-enhanced weights

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          Abstract

          Automatic segmentation of esophageal layers in OCT images is crucial for studying esophageal diseases and computer-assisted diagnosis. This work aims to improve the current techniques to increase the accuracy and robustness for esophageal OCT image segmentation. A two-step edge-enhanced graph search (EEGS) framework is proposed in this study. Firstly, a preprocessing scheme is applied to suppress speckle noise and remove the disturbance in the esophageal structure. Secondly, the image is formulated into a graph and layer boundaries are located by graph search. In this process, we propose an edge-enhanced weight matrix for the graph by combining the vertical gradients with a Canny edge map. Experiments on esophageal OCT images from guinea pigs demonstrate that the EEGS framework is more robust and more accurate than the current segmentation method. It can be potentially useful for the early detection of esophageal diseases.

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          Most cited references46

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          Optical coherence tomography of the human retina.

          To demonstrate optical coherence tomography for high-resolution, noninvasive imaging of the human retina. Optical coherence tomography is a new imaging technique analogous to ultrasound B scan that can provide cross-sectional images of the retina with micrometer-scale resolution. Survey optical coherence tomographic examination of the retina, including the macula and optic nerve head in normal human subjects. Research laboratory. Convenience sample of normal human subjects. Correlation of optical coherence retinal tomographs with known normal retinal anatomy. Optical coherence tomographs can discriminate the cross-sectional morphologic features of the fovea and optic disc, the layered structure of the retina, and normal anatomic variations in retinal and retinal nerve fiber layer thicknesses with 10-microns depth resolution. Optical coherence tomography is a potentially useful technique for high depth resolution, cross-sectional examination of the fundus.
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            Is Open Access

            Automatic segmentation of seven retinal layers in SDOCT images congruent with expert manual segmentation

            Segmentation of anatomical and pathological structures in ophthalmic images is crucial for the diagnosis and study of ocular diseases. However, manual segmentation is often a time-consuming and subjective process. This paper presents an automatic approach for segmenting retinal layers in Spectral Domain Optical Coherence Tomography images using graph theory and dynamic programming. Results show that this method accurately segments eight retinal layer boundaries in normal adult eyes more closely to an expert grader as compared to a second expert grader.
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              Automated 3-D intraretinal layer segmentation of macular spectral-domain optical coherence tomography images.

              With the introduction of spectral-domain optical coherence tomography (OCT), much larger image datasets are routinely acquired compared to what was possible using the previous generation of time-domain OCT. Thus, the need for 3-D segmentation methods for processing such data is becoming increasingly important. We report a graph-theoretic segmentation method for the simultaneous segmentation of multiple 3-D surfaces that is guaranteed to be optimal with respect to the cost function and that is directly applicable to the segmentation of 3-D spectral OCT image data. We present two extensions to the general layered graph segmentation method: the ability to incorporate varying feasibility constraints and the ability to incorporate true regional information. Appropriate feasibility constraints and cost functions were learned from a training set of 13 spectral-domain OCT images from 13 subjects. After training, our approach was tested on a test set of 28 images from 14 subjects. An overall mean unsigned border positioning error of 5.69+/-2.41 microm was achieved when segmenting seven surfaces (six layers) and using the average of the manual tracings of two ophthalmologists as the reference standard. This result is very comparable to the measured interobserver variability of 5.71+/-1.98 microm.
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                Author and article information

                Journal
                Biomed Opt Express
                Biomed Opt Express
                BOE
                Biomedical Optics Express
                Optical Society of America
                2156-7085
                27 August 2018
                01 September 2018
                27 August 2018
                : 9
                : 9
                : 4481-4495
                Affiliations
                [1 ]Department of Electronic and Information Engineering, Soochow University, Suzhou 215006, China
                [2 ]Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China
                [3 ]Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
                Author notes
                [4]

                These authors contributed equally to this work and should be considered co-first authors

                Article
                332993
                10.1364/BOE.9.004481
                6157790
                e58429fd-ea48-4f21-be64-c624fa1a8970
                © 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

                © 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

                History
                : 01 June 2018
                : 17 August 2018
                : 20 August 2018
                Funding
                Funded by: Ministry of Science and Technology of the People's Republic of China (MOST) 10.13039/501100002855
                Award ID: 2016YFE0107700
                Funded by: National Institutes of Health (NIH) 10.13039/100000002
                Award ID: CA153023
                Award ID: HL121788
                Funded by: Wallace H. Coulter Foundation (WHCF) 10.13039/100001062
                Categories
                Article

                Vision sciences
                (100.0100) image processing,(100.2960) image analysis,(170.4500) optical coherence tomography,(170.4580) optical diagnostics for medicine

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