Blog
About

  • Record: found
  • Abstract: found
  • Article: found
Is Open Access

Neuroinflammation in Alzheimer’s disease

Read this article at

ScienceOpenPublisherPMC
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      Amyloid-β plaques and neurofibrillary tangles are the main neuropathological hallmarks in Alzheimer’s disease (AD), the most common cause of dementia in the elderly. However, it has become increasingly apparent that neuroinflammation plays a significant role in the pathophysiology of AD. This review summarizes the current status of neuroinflammation research related to AD, focusing on the connections between neuroinflammation and some inflammation factors in AD. Among these connections, we discuss the dysfunctional blood–brain barrier and alterations in the functional responses of microglia and astrocytes in this process. In addition, we summarize and discuss the role of intracellular signaling pathways involved in inflammatory responses in astrocytes and microglia, including the mitogen-activated protein kinase pathways, nuclear factor-kappa B cascade, and peroxisome proliferator–activated receptor-gamma transcription factors. Finally, the dysregulation of the control and release of pro- and anti-inflammatory cytokines and classic AD pathology (amyloid plaques and neurofibrillary tangles) in AD is also reviewed.

      Related collections

      Most cited references 187

      • Record: found
      • Abstract: found
      • Article: not found

      Shared principles in NF-kappaB signaling.

      The transcription factor NF-kappaB has served as a standard for inducible transcription factors for more than 20 years. The numerous stimuli that activate NF-kappaB, and the large number of genes regulated by NF-kappaB, ensure that this transcription factor is still the subject of intense research. Here, we attempt to synthesize some of the basic principles that have emerged from studies of NF-kappaB, and we aim to generate a more unified view of NF-kappaB regulation.
        Bookmark
        • Record: found
        • Abstract: not found
        • Article: not found

        Alzheimer's disease.

          Bookmark
          • Record: found
          • Abstract: found
          • Article: not found

          Microglia-mediated neurotoxicity: uncovering the molecular mechanisms.

          Mounting evidence indicates that microglial activation contributes to neuronal damage in neurodegenerative diseases. Recent studies show that in response to certain environmental toxins and endogenous proteins, microglia can enter an overactivated state and release reactive oxygen species (ROS) that cause neurotoxicity. Pattern recognition receptors expressed on the microglial surface seem to be one of the primary, common pathways by which diverse toxin signals are transduced into ROS production. Overactivated microglia can be detected using imaging techniques and therefore this knowledge offers an opportunity not only for early diagnosis but, importantly, for the development of targeted anti-inflammatory therapies that might slow or halt the progression of neurodegenerative disease.
            Bookmark

            Author and article information

            Affiliations
            [1 ]Department of Pharmacy, General Hospital of Guangzhou Military Command, Guangzhou City, People’s Republic of China
            [2 ]School of Bioscience and Bioengineering, South China University of Technology, Guangzhou City, People’s Republic of China
            Author notes
            Correspondence: Linlan Jiang, Department of Pharmacy, General Hospital of Guangzhou Military Command No 111, Liuhua Road, Yuexiu District, Guangzhou City 510010, People’s Republic of China, Tel/Fax +86 20 8865 3475, Email jlinlan@ 123456vip.tom.com
            Journal
            Neuropsychiatr Dis Treat
            Neuropsychiatr Dis Treat
            Neuropsychiatric Disease and Treatment
            Neuropsychiatric Disease and Treatment
            Dove Medical Press
            1176-6328
            1178-2021
            2015
            30 January 2015
            : 11
            : 243-256
            4321665 10.2147/NDT.S75546 ndt-11-243
            © 2015 Zhang and Jiang. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

            The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

            Categories
            Review

            Comments

            Comment on this article