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      Validity of a new immunochromatographic test in detection of Toxoplasma gondii in cancer patients

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          Abstract

          Screening of toxoplasmosis in cancer patients is mandatory especially before starting treatment to guard against life-threatening disseminated disease. Diagnosis of toxoplasmosis rely mainly on serology. The most widely used method for detection of anti- Toxoplasma gondii ( T. gondii) antibodies is the enzyme linked immunosorbent assay (ELISA), being available and reliable. Immunochromatographic tests (ICT) attracted a lot of attention recently being one of the high quality, rapid and easy to perform tests. Available data comparing the performance of ICT versus ELISA techniques have yielded inconsistent results and none compared their performance among the immunocompromised cancer patients. Therefore, we designed this study to compare the performance of a new ICT (the OnSite Toxo IgG/IgM Combo Rapid test) and ELISA techniques for the detection of anti- T. gondii antibody as a tool for screening for toxoplasmosis among cancer patients in Cairo-Egypt. Among 180 cancer patients, a total of 110 patients (61.1%) were positive for anti- T. gondii antibodies by one or both methods. Agreement between both methods was found in 78.8% of the samples. By using ELISA technique as a gold standard test for the detection of anti- T. gondii antibodies, our results showed 87.5% specificity and 74% sensitivity of ICT technique. Moreover, our results proved that ICT is more sensitive in detecting lower level of antibodies than ELISA, that makes it preferable as a screening test for the immunocompromised patients.

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          Author and article information

          Contributors
          +20 1005782994 , rita.wassef@med.helwan.edu.eg
          Journal
          J Parasit Dis
          J Parasit Dis
          Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
          Springer India (New Delhi )
          0971-7196
          0975-0703
          30 November 2018
          March 2019
          : 43
          : 1
          : 83-86
          Affiliations
          [1 ] ISNI 0000 0000 9853 2750, GRID grid.412093.d, Parasitology Department, Faculty of Medicine, , Helwan University, ; Cairo, Egypt
          [2 ] ISNI 0000 0004 0639 9286, GRID grid.7776.1, Clinical Oncology Department, Faculty of Medicine, , Cairo University, ; Giza, Egypt
          Author information
          http://orcid.org/0000-0002-8431-2428
          Article
          PMC6423148 PMC6423148 6423148 1063
          10.1007/s12639-018-1063-2
          6423148
          30956450
          e5b7b926-8b41-436c-8630-113f048239e4
          © Indian Society for Parasitology 2018
          History
          : 3 October 2018
          : 24 November 2018
          Categories
          Original Article
          Custom metadata
          © Indian Society for Parasitology 2019

          Cancer, Toxoplasma gondii ,ICT,ELISA
          Cancer, Toxoplasma gondii , ICT, ELISA

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