Infantile hepatic hemangioma misdiagnosed by prenatal ultrasonography

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Rationale:

The drastic differences in treatment and prognosis of infantile hepatic hemangioma (IHH) and hepatoblastoma (HBL) make accurate prenatal diagnosis imperative. The retrospective comparisons of ultrasonic features between fetal IHH and HBL have been reported before, but clinically, the differential diagnosis in utero is very difficult and can lead to prenatal misdiagnosis.

Patient concerns:

A 27-year-old woman at 30 gestational weeks underwent the routine prenatal examination. A heterogeneous solid mass of the fetus, with close relationship to the liver, was recognized by ultrasound.

Diagnosis:

A diagnosis of HBL was highly considered.

Interventions:

The fetus was aborted and the autopsy was performed.

Outcomes:

The histological outcome was IHH.

Lessons:

The prognosis of fetal IHH and HBL is very different, so an accurate diagnosis prenatally is crucial and indispensable. The radiologist and clinician should differentiate between IHH and HBL, especially since the fetus can have serious complications.

Related collections

Most cited references 21

Record: found
Abstract: found
Article: not found

Hepatoblastoma: recent developments in research and treatment.

Dietrich von Schweinitz (2012)

Hepatoblastoma is the most common liver tumor of early childhood. According to recent studies its incidence seems to be increasing in North America and Europe. Since new histological variants have been described recently the formerly clear-cut distinction of hepatoblastoma and hepatocellular carcinoma may not be valid anymore and a new histological classification will be inaugurated by an international working group. Recent research identified prognostically relevant gene signatures as well as potential molecular targets for therapy of hepatoblastoma. The multicentric study groups in the USA, Europe and Japan recommend cisplatin based chemotherapy for neoadjuvant and adjuvant treatment. However, their risk stratification systems and general treatment strategies differ substantially. Therefore the four groups agreed to pool their patients' data for an analysis of prognostic criteria which can be used for defining common risk groups. While 90% of standard risk and 65% of high risk hepatoblastomas can be cured, the still dismal outcome of multifocal disseminated and metastasising tumors warrants the investigation of new cytotoxic drugs and substances against specific molecular targets. Copyright © 2012 Elsevier Inc. All rights reserved.

0 comments Cited 31 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Hepatic vascular tumors.

Belinda Hsi Dickie, Steven J. Fishman, Richard G Azizkhan (2014)

The most common hepatic vascular tumor in the pediatric population is the infantile hepatic hemangioma. Although these lesions have a spectrum of presentations, there are three main subtypes that have been described-focal, multifocal, and diffuse. An algorithm on the workup, treatment, and follow-up of these lesions can be based on this categorization. Recent shifts in the management of hemangiomas with beta-blockers (propranolol) have also influenced the treatment of hepatic hemangiomas. This article reviews the current understanding of hepatic hemangiomas and protocols in the management of these patients.

0 comments Cited 14 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Fetal and neonatal liver tumours.

Erica Makin, Mark Davenport (2010)

Liver tumours are rare in children and account for about 5% of all tumours in the fetus and newborn. The most frequently occurring are benign vascular tumours and mesenchymal hamartomas although malignancy in the form of hepatoblastoma is a possibility. While the diagnosis can be suspected antenatally (by ultrasound and MR scan), a precise diagnosis is often difficult due to the complexity of the tumours. Inutero development of such tumours may be associated with polyhydramnios, fetal hydrops and extreme cases the maternal mirror syndrome. Postnatal symptoms may include abdominal distension, cardiac failure, consumptive coagulopathy and bleeding due to tumour rupture, but is dependent on the nature of the actual tumour. Treatment options may include watchful waiting, surgical resection, hepatic artery embolisation/ligation and chemotherapy.

0 comments Cited 13 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Journal ID (nlm-ta): Medicine (Baltimore)

Journal ID (iso-abbrev): Medicine (Baltimore)

Journal ID (publisher-id): MEDI

Title: Medicine

Publisher: Lippincott Williams & Wilkins (Hagerstown, MD )

ISSN (Print): 0025-7974

ISSN (Electronic): 1536-5964

Publication date Collection: 15 January 2021

Publication date (Electronic): 15 January 2021

Volume: 100

Issue: 2

Electronic Location Identifier: e24242

Affiliations

[a ]Department of Ultrasound

[b ]Key Laboratory of Obstetrics and Gynecology and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital of Sichuan University

[c ]Department of Pathology, West China Hospital of Sichuan University

[d ]Chengdu Chenghua District Maternal and Child Health Hospital, Chengdu, Sichuan, China.

Author notes

[∗ ]Correspondence: Fan Yang, Department of Ultrasound, West China Second Hospital of Sichuan University, Renmin South Road, Section 3, Number 20, Chengdu, Sichuan, 610041, China/Chengdu Chenghua District Maternal and Child Health Hospital, Chengdu, Sichuan, China (e-mail: jessica1975cd@ 123456163.com ).

Article

Publisher ID: MD-D-20-00384 Accession ID: 24242

DOI: 10.1097/MD.0000000000024242

PMC ID: 7808497

PubMed ID: 33466207

SO-VID: e5bbc82e-b9a5-4042-a2d3-03892848382a

License:

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0

History

Date received : 28 January 2020

Date revision received : 6 December 2020

Date accepted : 17 December 2020

Funding

Funded by: The New sprout fund of West China Second University Hospital

Award ID: kx067

Award Recipient : Ya Jin

Funded by: National Key Research and Development Plan

Award ID: 2017YFC0113905

Award Recipient : Hong Luo

Funded by: International Cooperation Project of Sichuan Science and Technology Department

Award ID: 20GJHZ0198

Award Recipient : Fan Yang

Custom metadata

OPEN-ACCESS TRUE

Keywords: differential diagnosis,fetus,hepatoblastoma,infantile hepatic hemangioma,ultrasound

Data availability:

Keywords: differential diagnosis, fetus, hepatoblastoma, infantile hepatic hemangioma, ultrasound

Infantile hepatic hemangioma misdiagnosed by prenatal ultrasonography : A case report

Read this article at

Abstract

Rationale:

Patient concerns:

Diagnosis:

Interventions:

Outcomes:

Lessons:

Related collections

Network Medicine

Most cited references 21

Hepatoblastoma: recent developments in research and treatment.

Hepatic vascular tumors.

Fetal and neonatal liver tumours.

Author and article information

Journal

Affiliations

Author notes

Article

History

Funding

Categories

Custom metadata

Comments

Comment on this article

Similar content 155

Cited by 1

Most referenced authors 153