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      Conformational Studies of Oligosaccharides

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          Abstract

          The conformation of a molecule strongly affects its function, as demonstrated for peptides and nucleic acids. This correlation is much less established for carbohydrates, the most abundant organic materials in nature. Recent advances in synthetic and analytical techniques have enabled the study of carbohydrates at the molecular level. Recurrent structural features were identified as responsible for particular biological activities or material properties. In this Minireview, recent achievements in the structural characterization of carbohydrates, enabled by systematic studies of chemically defined oligosaccharides, are discussed. These findings can guide the development of more potent glycomimetics. Synthetic carbohydrate materials by design can be envisioned.

          Abstract

          Chemical synthesis and novel analytical techniques have enabled conformational studies of oligosaccharides. Recurrent structural features have been identified. Tuning these structures will allow for the production of more potent glycomimetics and materials by design.

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          Author and article information

          Contributors
          martina.delbianco@mpikg.mpg.de
          Journal
          Chemistry
          Chemistry
          10.1002/(ISSN)1521-3765
          CHEM
          Chemistry (Weinheim an Der Bergstrasse, Germany)
          John Wiley and Sons Inc. (Hoboken )
          0947-6539
          1521-3765
          09 July 2020
          06 August 2020
          : 26
          : 44 , Young Chemists 2020 ( doiID: 10.1002/chem.v26.44 )
          : 9814-9825
          Affiliations
          [ 1 ] Department of Biomolecular Systems Max-Planck-Institute of Colloids and Interfaces Am Mühlenberg 1 14476 Potsdam Germany
          [ 2 ] Department of Chemistry and Biochemistry Freie Universität Berlin Arnimallee 22 14195 Berlin Germany
          Author information
          http://orcid.org/0000-0002-4580-9597
          Article
          CHEM202001370
          10.1002/chem.202001370
          7496230
          32329095
          e5bc1ff1-4331-4b8c-8f55-bcbba4388b81
          © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

          This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

          History
          : 19 March 2020
          : 20 April 2020
          Page count
          Figures: 18, Tables: 0, References: 138, Pages: 12, Words: 0
          Funding
          Funded by: Max-Planck-Gesellschaft , open-funder-registry 10.13039/501100004189;
          Categories
          Minireview
          Minireviews
          Glycans
          Custom metadata
          2.0
          August 6, 2020
          Converter:WILEY_ML3GV2_TO_JATSPMC version:5.9.0 mode:remove_FC converted:11.09.2020

          Chemistry
          conformations,glycans,structural studies,synthetic oligosaccharides
          Chemistry
          conformations, glycans, structural studies, synthetic oligosaccharides

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