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      Pseudohyperkalemia occurring in a patient with chronic renal failure and polycythemia vera without severe leukocytosis or thrombocytosis.

      Clinical Nephrology
      Aged, Humans, Hyperkalemia, complications, diagnosis, Kidney Failure, Chronic, Leukocytosis, Male, Polycythemia Vera, Potassium, blood, Thrombocytosis

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          Abstract

          Pseudohyperkalemia is defined as a serum potassium concentration 0.4 mEq/l greater than the plasma concentration. The basis of this phenomenon is the release of intracellular potassium from platelets, leukocytes, or erythrocytes, commonly in the setting of extreme leukocytosis (> 10 x 10(4)/microl) or thrombocytosis (> 60 x 10(4)/microl). We report a case of pseudohyperkalemia in a patient with chronic renal failure and polycythemia vera without the finding of severe leukocytosis or thrombocytosis (white blood cell count 1.88 x 10(4)/microl and platelet count 37.9 x 10(4)/microl, respectively). The serum potassium concentration was 8.2 mEq/l, while the plasma potassium level was 6.4 mEq/l in a sample obtained simultaneously. The concentrations of platelet factor IV and beta-thromboglobulin, known to be markers of platelet activation, were greater than 100 ng/ml and 200 ng/ml, respectively, indicating that platelet activation may have been related to the development of pseudohyperkalemia in this patient. These findings suggest that pseudohyperkalemia should be considered when hyperkalemia is seen in a patient with chronic renal failure and myeloproliferative disorders.

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          Author and article information

          Journal
          12508968
          10.5414/CNP58451

          Chemistry
          Aged,Humans,Hyperkalemia,complications,diagnosis,Kidney Failure, Chronic,Leukocytosis,Male,Polycythemia Vera,Potassium,blood,Thrombocytosis

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