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      Ontogenesis of Hypertension and Responsiveness to Antihypertensive Agents in Spontaneously Hypertensive Rats

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          Abstract

          Heart rate, systolic blood pressure and responses of spontaneously hypertensive rats (SHR) to guanethidine, timolol, minoxidil and phentolamine were monitored at 2, 6 and 12 months of age. All antihypertensive agents produced significant and comparable reductions in systolic blood pressure at 6 and 9 months of age, at which time systolic blood pressures were maximally elevated, but had very little effect at 2 months when pressures were only marginally higher. However, at 12 months of age, SHR maintained their response to guanethidine and timolol but responded less well to minoxidil and, especially, to phentolamine. Aortic strips of SHR contracted less than those of normotensive rats to both KC1 and norepinephrine at all ages and also relaxed less to nitroglycerin. SHR aortic strips appeared to specifically lose the ability to contract to norepinephrine at 12 months of age. It is suggested that a progression of change in responsiveness to antihypertensive agents exists for SHR. Furthermore, this progression will differ for agents with differing mechanisms of action and is probably a result of physical and/or biochemical factors which combine to alter the responsivity of SHR vascular smooth muscle.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1980
          1980
          19 September 2008
          : 17
          : 2
          : 78-90
          Affiliations
          Research Department, Pharmaceuticals Division, Ciba-Geigy Corporation, Summit, N.J.
          Article
          158237 Blood Vessels 1980;17:78–90
          10.1159/000158237
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 13
          Categories
          Research Paper

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