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      ST2 protein induced by inflammatory stimuli can modulate acute lung inflammation

      , , ,
      Biochemical and Biophysical Research Communications
      Elsevier BV

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          Abstract

          We have investigated gene and protein expression of ST2/ST2L in a murine alveolar macrophage (AM) cell line, MH-S, reacting to inflammatory stimuli in vitro and in the lung tissue of an acute lung injury model in vivo. We have also analyzed the effect of soluble ST2 protein on inflammatory response of MH-S cells. Lipopolysaccharide (LPS) and proinflammatory cytokines such as IL-1beta, IL-6, and TNF-alpha induced ST2 mRNA expression in MH-S cells. In an acute lung injury model, protein and mRNA expression levels of ST2 increased to the maximal level at 24-72h after the LPS challenge. Furthermore, pretreatment with ST2 protein significantly reduced the protein production and gene expression of IL-1alpha, IL-6, and TNF-alpha in LPS-stimulated MH-S cells in vitro. These results suggest that increases in endogenous ST2 protein in AM, which is induced by inflammatory stimuli, such as LPS and proinflammatory cytokines, may modulate acute lung inflammation.

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          Author and article information

          Journal
          Biochemical and Biophysical Research Communications
          Biochemical and Biophysical Research Communications
          Elsevier BV
          0006291X
          November 2002
          November 2002
          : 299
          : 1
          : 18-24
          Article
          10.1016/S0006-291X(02)02578-0
          12435383
          e5eb9530-13a7-43b1-8d51-cbbb4766417c
          © 2002

          https://www.elsevier.com/tdm/userlicense/1.0/

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