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      Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo

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          Abstract

          For a long time, fucoidan has been well known for its pharmacological activities, and recently low molecular weight fucoidan (LMF) has been used in food supplements and pharmaceutical products. In the present study, LMF was extracted from Laminaria japonica by enzyme hydrolysis. The toxicity of LMF in mouse and rat models was determined by many methods, such as total arsenic content, bacterial reverse mutation assay, chromosome aberration assay, and in vivo micronucleus assay. The present findings showed that LMF at 5000 μg/mL exhibited no mutagenicity. It also produced no formatting disruption of red blood cells in vivo. At 2000 mg/kg BW/day there were no toxicological indications. LMF is expected to be used as a safe food supplement.

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          Most cited references44

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          Therapies from Fucoidan; Multifunctional Marine Polymers

          Published research on fucoidans increased three fold between 2000 and 2010. These algal derived marine carbohydrate polymers present numerous valuable bioactivities. This review discusses the role for fucoidan in the control of acute and chronic inflammation via selectin blockade, enzyme inhibition and inhibiting the complement cascade. The recent data on toxicology and uptake of fucoidan is detailed together with a discussion on the comparative activities of fractions of fucoidan from different sources. Recent in vivo, in vitro and clinical research related to diverse clinical needs is discussed. Targets include osteoarthritis, kidney and liver disease, neglected infectious diseases, hemopoietic stem cell modulation, protection from radiation damage and treatments for snake envenomation. In recent years, the production of well characterized reproducible fucoidan fractions on a commercial scale has become possible making therapies from fucoidan a realizable goal.
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            Seaweed in food products: biochemical and nutritional aspects

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              Biological activities and potential industrial applications of fucose rich sulfated polysaccharides and fucoidans isolated from brown seaweeds: A review

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                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                Mar Drugs
                Mar Drugs
                marinedrugs
                Marine Drugs
                MDPI
                1660-3397
                24 June 2016
                July 2016
                : 14
                : 7
                : 121
                Affiliations
                [1 ]Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung 20246, Taiwan; amperehwang@ 123456gmail.com
                [2 ]Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan; yanmd717@ 123456gmail.com
                [3 ]Department of Food Science, National Taiwan Ocean University, Keelung 20246, Taiwan; HL358@ 123456ntou.edu.tw
                [4 ]Graduate Institute of Biotechnology, Chinese Culture University, Taipei 11114, Taiwan; noodleplusalan@ 123456gmail.com
                Author notes
                [* ]Correspondence: lyc10@ 123456ulive.pccu.edu.tw ; Tel.: +886-2-2861-0511 (ext. 31832); Fax: +886-2-2861-8266
                Article
                marinedrugs-14-00121
                10.3390/md14070121
                4962011
                27347980
                e6065a1d-4837-4008-b999-8ef48daa9ba3
                © 2016 by the authors; licensee MDPI, Basel, Switzerland.

                This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 25 April 2016
                : 17 June 2016
                Categories
                Article

                Pharmacology & Pharmaceutical medicine
                low molecular weight fucoidan,toxicity,laminariajaponica

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