125
views
0
recommends
+1 Recommend
1 collections
    8
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Six new monacolin analogs from red yeast rice

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Six novel monacolin analogs, monacolins V 1-V 6 ( 1–6), together with seven known ones ( 7–13), were isolated from the ethyl acetate extract of red yeast rice. Their structures and absolute configurations were determined by spectroscopic methods, especially 2D NMR ( 1H- 1HCOSY, HSQC, HMBC, and NOESY/ROESY) and CD spectroscopic analyses as well as chemical derivation. Monacolins V 2 ( 2) and V 3 ( 3) represent the first examples of monacolins with 3-hydroxybutyrate substitute. The anti-inflammatory inhibitory activities against the lipopolysaccharide (LPS) induced NO production in BV-2 cells as well as antioxidant activities against rat liver microsomal lipid peroxidation were evaluated.

          Related collections

          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 May 2019
          : 17
          : 5
          : 394-400
          Affiliations
          1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
          Author notes
          *Corresponding author: HU You-Cai, E-mail: huyoucai@ 123456imm.ac.cn

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(19)30046-9
          10.1016/S1875-5364(19)30046-9
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: CAMS Initiative for Innovative Medicine
          Award ID: 2017-I2M-4-004
          Funded by: Drug Innovation Major Project
          Award ID: 2018ZX09711001-006
          This work was supported financially by CAMS Initiative for Innovative Medicine (No. 2017-I2M-4-004) and the Drug Innovation Major Project (No. 2018ZX09711001-006).

          Comments

          Comment on this article