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      Liquorice, Growth Retardation and Addison’s Disease

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          Abstract

          An 11-year-old boy had hypoparathyroidism and Addison’s disease. During treatment with calcitriol, calcium, hydrocortisone and 9-α-fluorocortisol, he developed an apparent mineralocorticoid excess and growth retardation. Pseudohyperaldosteronism even persisted after treatment with 9-α-fluorocortisol was stopped and hydrocortisone was reduced to 6 mg/m<sup>2</sup>. The boy reported an excessive daily intake of 300–400 g liquorice corresponding to 600–800 mg glycyrrhizic acid because of salt craving. After complete withdrawal of liquorice all symptoms of hypermineralocorticoidism diminished and growth velocity increased. We hypothesise that inhibition of 11β-hydroxysteroid dehydrogenase by liquorice caused hypermineralocorticoidism and growth retardation via increased levels of free cortisol in this patient. We conclude that self-medication with liquorice in children with Addison’s disease should be considered during treatment.

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          Medicinal uses of licorice through the millennia: the good and plenty of it.

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            Author and article information

            Journal
            HRE
            Horm Res Paediatr
            10.1159/issn.1663-2818
            Hormone Research in Paediatrics
            S. Karger AG
            1663-2818
            1663-2826
            1999
            November 1999
            17 May 2000
            : 52
            : 5
            : 253-255
            Affiliations
            Department of Endocrinology, Vestische Kinderklinik Datteln, University of Witten-Herdecke, Germany
            Article
            23470 Horm Res 1999;52:253–255
            10.1159/000023470
            10844416
            © 2000 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            Page count
            Figures: 1, References: 7, Pages: 3
            Categories
            Case Report

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