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      Michael Heidelberger and the demystification of antibodies

      review-article
      The Journal of Experimental Medicine
      The Rockefeller University Press

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          Abstract

          Having defined the protein nature of antibodies under the tutelage of Oswald Avery, Michael Heidelberger was the first to apply mathematics to the reaction of antibodies and their antigens (the “precipitin reaction”). Heidelberger's calculations launched decades of research that helped reveal the specificity, function, and origin of antibodies.

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          Most cited references9

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          Annu. Rev. Biochem.

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            Haldan Keffer Hartline: December 22, 1903-March 18, 1983.

            F RATLIFF (1989)
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              A "pure" organic chemist's downward path: chapter 2--the years at P. and S.

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                Author and article information

                Journal
                J Exp Med
                The Journal of Experimental Medicine
                The Rockefeller University Press
                0022-1007
                1540-9538
                23 January 2006
                : 203
                : 1
                : 5
                Affiliations
                Article
                jem2031fta
                10.1084/jem.2031fta
                2118068
                16523537
                e61fa367-bd2c-45e2-833f-76dd00fb9971
                Copyright © 2006, The Rockefeller University Press
                History
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                Medicine
                Medicine

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