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      Growth Hormone-Releasing Hormone-Induced Growth Hormone Secretion in Adult Rats Orchidectomized or Injected with Ethylene Dimethane Sulphonate

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          Abstract

          It is well known that GHRH-induced GH secretion decreases after orchidectomy. To verify if testicular factors other than testosterone are involved in this effect, the GHRH-induced GH secretion and testosterone plasma levels were compared in adult male rats that were either intact, treated with ethylene dimethane sulphonate (EDS) (a specific toxin for Leydig cells), orchidectomized or testosterone-treated orchidectomized. We found that testosterone plasma levels and ventral prostate weight decreased to a similar extent in orchidectomized and EDS-treated males. GHRH-induced GH secretion only decreased in orchidectomized males. We conclude that testicular factors, other than androgens, increase GHRH-induced GH secretion.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1993
          1993
          08 April 2008
          : 57
          : 1
          : 132-134
          Affiliations
          Department of Physiology, Faculty of Medicine, University of Córdoba, Spain
          Article
          126352 Neuroendocrinology 1993;57:132–134
          10.1159/000126352
          8386817
          © 1992 S. Karger AG, Basel

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          Pages: 3
          Categories
          Original Paper

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