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      Intracelluiar Free Magnesium Concentrations in Skeletal Muscle in Chronic Uraemia

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          Abstract

          Low intracelluiar free magnesium concentrations ([Mg<sup>2+</sup>]<sub>i</sub>) are associated with essential hypertension and may reflect a disordered cellular ionic environment. <sup>31</sup>P magnetic resonance spectroscopy was used to study skeletal muscle [Mg<sup>2+</sup>]<sub>i</sub> in a group of chronic renal failure (CRF) patients and data were compared with a group of control subjects of similar age. Other data including the patients’ blood pressure, medication and plasma biochemistry were collected. There was a significant inverse correlation of [Mg<sup>2+</sup>]<sub>i</sub> with systolic (p < 0.001) and diastolic blood pressure (p < 0.05) in the CRF population. In CRF [Mg<sup>2+</sup>]<sub>i</sub> was similar (0.52 ± 0.01 m M, SEM) to controls (0.53 ± 0.01 m M; p = 0.20), even if just the normotensive patients and controls were compared. There was no correlation of [Mg<sup>2+</sup>]<sub>i</sub> with plasma parathyroid hormone, total [Mg<sup>2+</sup>] or [Ca<sup>2+</sup>]. Similar to studies in subjects with essential hypertension, these data support a role for [Mg2+]j specifically, and an abnormal intracelluiar enviroment more generally, in the pathophysiology of hypertension in CRF.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1997
          1997
          23 December 2008
          : 76
          : 1
          : 20-25
          Affiliations
          aDepartment of Nephrology, Churchill Hospital, and bMRC Biochemical and Clinical Magnetic Resonance Unit, John Radcliffe Hospital, Oxford, UK
          Article
          190135 Nephron 1997;76:20–25
          10.1159/000190135
          9171295
          © 1997 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Magnetic resonance, Skeletal muscle, Magnesium, Uraemia

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