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      Regulation of serotonin release in the Syrian hamster intergeniculate leaflet region.

        1 , ,
      Neuroreport

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          Abstract

          In mammals, the thalamic intergeniculate leaflet (IGL) conveys behavioral (non-photic) phase-resetting information to the circadian clock of the suprachiasmatic nucleus. Here we report a 24 h fluctuation in in vivo serotonin release in the hamster IGL region, peaking at night. Novel wheel exposure at midday, a stimulus that can reset circadian phase, activates the release of serotonin in the IGL region. In addition, electrical stimulation of the dorsal raphe nucleus acutely increases serotonin release the IGL region, confirming a functional serotonergic projection from this nucleus to the IGL. Collectively, these findings suggest that behavioral and/or circadian changes in dorsal raphe nuclear activity could modulate serotonin-mediated activities of the IGL.

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          Author and article information

          Journal
          Neuroreport
          Neuroreport
          0959-4965
          0959-4965
          Jan 19 2004
          : 15
          : 1
          Affiliations
          [1 ] Department of Biological Sciences, Kent State University, Kent, OH 44242, USA.
          Article
          10.1097/00001756-200401190-00021
          15106840
          e6352c4c-265e-4821-8346-1175de3af7a0
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