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      Impacto do laser de baixa intensidade na supressão de infecções pelos vírus Herpes simplex 1 e 2: estudo in vitro Translated title: Impact of low-intensity laser on the suppression of infections caused by Herpes simplex viruses 1 and 2: in vitro study

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          Abstract

          O uso do laser de baixa intensidade na supressão de infecções pelos vírus Herpes simplex 1 e 2 foi avaliado após uma a cinco aplicações, sendo observada uma redução gradual na replicação dos vírus Herpes simplex 1 e 2 com 68,4% e 57,3% de inibição, respectivamente, após 5 aplicações, indicando o seu uso clínico.

          Translated abstract

          The use of low-level laser to suppress infections caused by Herpes simplex viruses 1 and 2 was evaluated after one to five applications. A gradual reduction in replication of Herpes simplex viruses 1 and 2 was observed, with 68.4% and 57.3% inhibition, respectively, after five applications, thus favoring its clinical use.

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          Anti-viral activity of the extracts of a Kenyan medicinal plant Carissa edulis against herpes simplex virus.

          Joseph Muli, Faith Muli, Mawuli Kofi-Tsekpo … (2006)
          Herpes simplex virus (HSV) infection is a major opportunistic infection in immunosuppressed persons. It is therefore a serious disease in high HIV/AIDS prevalence areas as in sub-Saharan Africa where infections due to HSV have risen significantly. The development of resistant strains of HSV to the available drugs for infection management, as is evident in the first drug of choice acyclovir, has further compounded this situation. There is therefore an urgent need to identify and develop new alternative agents for management of HSV infections, more so, for those due to resistant strains. We report here on an aqueous total extract preparation from the roots of Carissa edulis (Forssk.) Vahl (Apocynaceae), a medicinal plant locally growing in Kenya that has exhibited remarkable anti-HSV activity in vitro and in vivo for both wild type and resistant strains of HSV. The extract significantly inhibited formation of plaques in Vero E6 cells infected with 100PFU of wild type strains of HSV (7401H HSV-1 and Ito-1262 HSV-2) or resistant strains of HSV (TK(-) 7401H HSV-1 and AP(r) 7401H HSV-1) by 100% at 50 microg/ml in vitro with minimal cell cytotoxicity (CC(50)=480 microg/ml). When the extract was examined for in vivo efficacy in a murine model using Balb/C mice cutaneously infected with wild type or resistant strains of HSV, the extract at an oral dose of 250 mg/kg significantly delayed the onset of HSV infections by over 50%. It also increased the mean survival time of treated infected mice by between 28 and 35% relative to the infected untreated mice (p<0.05 versus control by Student's t-test). The mortality rate for mice treated with extract was also significantly reduced by between 70 and 90% as compared with the infected untreated mice that exhibited 100% mortality. No acute toxicity was observed in mice at the oral therapeutic dose of 250 mg/kg. These results suggest that this herbal extract has potent anti-viral agents against herpes simplex viruses that can be exploited for development of an alternative remedy for HSV infections.
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            Photobiology of low-power laser effects.

            T Karu (1989)
            Quantitative studies have been performed to determine the action of low-intensity visible monochromatic light on various cells (E. coli, yeasts, HeLa, Chinese hamster fibroblasts and human lymphocytes); also irradiation conditions (wavelength, dose and intensity) conducive to vital activity stimulation have been examined. Respiratory chain components are discussed as primary photoacceptors. The possible ways for photosignal transduction and amplification are discussed. It is proposed that enhanced wound healing due to irradiation with low-intensity visible laser light (He-Cd, He-Ne and semiconductor lasers) is due to the increasing proliferation of cells.
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              Low-intensity laser therapy: a review.

              H Schön, M Schindl, A Schindl … (2000)
              Low-intensity laser radiation is characterized by its ability to induce athermic, nondestructive photobiological processes. Although it has been in use for more than 30 years, this phototherapy is still not an established therapeutic modality. We have summarized the main arguments being brought up against the use of this therapy and have reviewed the literature addressing both its in vitro and in vivo effects. We conclude that low-intensity laser irradiations might be of benefit in selected indications if the existing preliminary data can be confirmed by more prospective and well-controlled studies.
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                Author and article information

                Journal
                Journal ID (publisher-id): rsbmt
                Title: Revista da Sociedade Brasileira de Medicina Tropical
                Abbreviated Title: Rev. Soc. Bras. Med. Trop.
                Publisher: Sociedade Brasileira de Medicina Tropical - SBMT (Uberaba, MG, Brazil )
                ISSN (Print): 0037-8682
                ISSN (Electronic): 1678-9849
                Publication date (Print and electronic): February 2009
                Volume: 42
                Issue: 1
                Pages: 82-85
                Affiliations
                [02] Rio de Janeiro RJ orgnameUniversidade Federal do Rio de Janeiro orgdiv1Departamento de Virologia orgdiv2Instituto de Microbiologia Prof. Paulo de Góes
                [01] Niterói RJ orgnameUniversidade Federal Fluminense orgdiv1Departamento de Microbiologia orgdiv2Setor de Doenças Sexualmente Transmissíveis
                [03] Rio de Janeiro RJ orgnameUniversidade Federal do Rio de Janeiro orgdiv1Instituto de Microbiologia Prof. Paulo de Góes orgdiv2Departamento de Virologia
                Article
                Publisher ID: S0037-86822009000100018 Publisher ID: S0037-8682(09)04200118
                DOI: 10.1590/S0037-86822009000100018
                SO-VID: e643b915-5bda-4b9c-82ee-3c9442b114f7
                License:

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                Date received : 05 September 2008
                Date accepted : 13 January 2009
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 16, Pages: 4
                Product

                SciELO Brazil

                Categories
                Subject: Comunicação

                Keywords: Infections,Laser terapêutico de baixa intensidade,Herpes simplex tipo 1,Herpes simplex tipo 2,Infecções,Low-level laser therapy,Herpes simplex type 1,Herpes simplex type 2
                Data availability:
                Keywords: Infections, Laser terapêutico de baixa intensidade, Herpes simplex tipo 1, Herpes simplex tipo 2, Infecções, Low-level laser therapy, Herpes simplex type 1, Herpes simplex type 2

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