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      A Hydrogel-Based Localized Release of Colistin for Antimicrobial Treatment of Burn Wound Infection

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          Designing cell-compatible hydrogels for biomedical applications.

          Hydrogels are polymeric materials distinguished by high water content and diverse physical properties. They can be engineered to resemble the extracellular environment of the body's tissues in ways that enable their use in medical implants, biosensors, and drug-delivery devices. Cell-compatible hydrogels are designed by using a strategy of coordinated control over physical properties and bioactivity to influence specific interactions with cellular systems, including spatial and temporal patterns of biochemical and biomechanical cues known to modulate cell behavior. Important new discoveries in stem cell research, cancer biology, and cellular morphogenesis have been realized with model hydrogel systems premised on these designs. Basic and clinical applications for hydrogels in cell therapy, tissue engineering, and biomedical research continue to drive design improvements using performance-based materials engineering paradigms.
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            Hydrogels: from controlled release to pH-responsive drug delivery.

            Hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. Besides exhibiting swelling-controlled drug release, hydrogels also show stimuli-responsive changes in their structural network and hence, the drug release. Because of large variations in physiological pH at various body sites in normal as well as pathological conditions, pH-responsive polymeric networks have been extensively studied. This review highlights the use of hydrogels (a class of polymeric systems) in controlled drug delivery, and their application in stimuli-responsive, especially pH-responsive, drug release.
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              Hydrogels for protein delivery.

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                Author and article information

                Journal
                Macromolecular Bioscience
                Macromol. Biosci.
                Wiley
                16165187
                February 2017
                February 2017
                September 13 2016
                : 17
                : 2
                : 1600320
                Affiliations
                [1 ]Department of Chemistry; University of Warwick; CV4 7AL Coventry UK
                [2 ]ARC Centre of Excellence in Convergent Bio-Nano Science and Technology; Monash Institute of Pharmaceutical Sciences; Monash University; Parkville VIC 3052 Australia
                Article
                10.1002/mabi.201600320
                e64d439e-c521-48ef-840a-61cb859be7c7
                © 2016

                http://doi.wiley.com/10.1002/tdm_license_1

                http://creativecommons.org/licenses/by/4.0/

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