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      Effects of Pravastatin on Superoxide and Fibronectin Production of Mesangial Cells Induced by Low-Density Lipoprotein

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          Pravastatin is a potent inhibitor of HMG-CoA reductase and is effective in lowering serum lipid levels. Recent studies have shown that pravastatin also reduces the oxidative modification of low-density lipoprotein (LDL). To determine whether pravastatin has a direct effect on glomerular mesangial cells, we have measured the effects of pravastatin on the production of superoxide and fibronectin of glomerular mesangial cells stimulated by LDL. Our results demonstrated that the superoxide production of mesangial cells increased after LDL stimulation (100 µg/ml for 4 h) and that the superoxide production was significantly suppressed by either superoxide dismutase (SOD; 500 U/ml for 36 h; p < 0.01) or pravastatin (80 µ M for 36 h; p < 0.05). The production of fibronectin was also increased after LDL stimulation which was also significantly suppressed by either SOD (p < 0.01) or pravastatin (p < 0.01). SOD or pravastatin alone had no effect on the unstimulated cells. Our results indicate that pravastatin may have a direct effect as an antioxidant and suppresses the fibronectin synthesis of glomerular mesangial cells independent of its hypolipidemic effect.

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          Comparing antiepileptic drugs


            Author and article information

            Kidney Blood Press Res
            Kidney and Blood Pressure Research
            S. Karger AG
            06 February 2002
            : 25
            : 1
            : 2-6
            aDepartment of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; bDepartment of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
            49428 Kidney Blood Press Res 2002;25:2–6
            © 2002 S. Karger AG, Basel

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            Page count
            Figures: 5, References: 15, Pages: 5
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            Original Paper

            Cardiovascular Medicine, Nephrology

            Low-density lipoprotein, Fibronectin, Superoxide, Pravastatin


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