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      Cross-talk between LOX-1 and PCSK9 in vascular tissues.

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          Abstract

          Lectin-like ox-LDL receptor-1 (LOX-1) plays an important role in inflammatory diseases, such as atherosclerosis. Proprotein convertase subtilisin/kexin type 9 (PCSK9) modulates LDL receptor degradation and influences serum LDL levels. The present study was designed to investigate the possible interaction between PCSK9 and LOX-1.

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          Author and article information

          Journal
          Cardiovasc. Res.
          Cardiovascular research
          Oxford University Press (OUP)
          1755-3245
          0008-6363
          Sep 01 2015
          : 107
          : 4
          Affiliations
          [1 ] Central Arkansas Veterans Healthcare System and the University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
          [2 ] Central Arkansas Veterans Healthcare System and the University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China sliu2@uams.edu mehtajl@uams.edu.
          [3 ] Central Arkansas Veterans Healthcare System and the University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
          [4 ] Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
          [5 ] Department of Physiology, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto 390-8621, Japan.
          [6 ] Central Arkansas Veterans Healthcare System and the University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA sliu2@uams.edu mehtajl@uams.edu.
          Article
          cvv178
          10.1093/cvr/cvv178
          26092101
          e65f32ae-cca0-4408-92c7-8b052e9ea57a
          History

          Mitochondrial ROS,PCSK9,VCAM-1,LOX-1
          Mitochondrial ROS, PCSK9, VCAM-1, LOX-1

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