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      Evaluation of the therapeutic effects of Aloe vera gel on minor recurrent aphthous stomatitis


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          Aphthous ulcer is one of the most common diseases of the oral cavity with no known effective treatment so far, which could cause severe discomfort in patients. Aloe vera (A.V.) is a tropical plant with anti-inflammatory and immunostimulant effects, which could be of benefit in a diversity of wound healing conditions. The aim of this study is to evaluate topically administered A.V. gel on oral cavity minor aphthous healing.

          Materials and Methods:

          As a double-blind (case control) clinical trial, 40 patients with oral minor aphthous lesions were randomly allocated in either the case group (A.V. gel) or the control (placebo) group. The healing time (days after gel application), patient's pain score; the lesion and its surrounding inflammation diameters were recorded for 2 weeks. The obtained results were analyzed by either “Fishers exact” or t-student test using SPSS software.


          The mean (±SD) of patients’ age was 29.25 ± 8.48 and 27.95 ± 7.96 years in the control and A.V.-treated groups, respectively, which were not significantly different ( P > 0.05). The duration of complete wound healing, pain score, wound size and inflammation zone diameter in the A.V.-treated group were significantly lower than the control group ( P ≤ 0.05) on specific time points after treatment.


          It seems likely that A.V. 2% oral gel is not only effective in decreasing the recurrent aphthous stomatitis patients’ pain score and wound size but also decreases the aphthous wound healing period.

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          Most cited references21

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          Aloe vera leaf gel: a review update

          Journal of Ethnopharmacology, 68(1-3), 3-37
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            Mucosal disease series. Number VI. Recurrent aphthous stomatitis.

            Recurrent aphthous stomatitis (RAS; aphthae; canker sores) is a common condition which is characterized by multiple recurrent small, round or ovoid ulcers with circumscribed margins, erythematous haloes, and yellow or grey floors typically presenting first in childhood or adolescence. RAS occurs worldwide although it appears most common in the developed world. The aetiology of RAS is not entirely clear. Despite many studies trying to identify a causal microorganism, RAS does not appear to be infectious. A genetic predisposition is present, as shown by strong associations with genotypes of IL-1beta; IL-6 in RAS patients, and a positive family history in about one-third of patients with RAS. Haematinic deficiency is found in up to 20% of patients. Cessation of smoking may precipitate or exacerbate RAS in some cases. Ulcers similar to RAS may be seen in human immunodeficiency virus disease and some other immune defects, and drugs, especially non-steroidal anti-inflammatory drugs and nicorandil may produce lesions clinically similar to RAS. Topical corticosteroids can often control RAS. However, the treatment of RAS remains unsatisfactory, as most therapies only reduce the severity of the ulceration and do not stop recurrence.
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              Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro.

              Oral aloe vera gel is widely used by patients with inflammatory bowel disease and is under therapeutic evaluation for this condition. To assess the effects of aloe vera in vitro on the production of reactive oxygen metabolites, eicosanoids and interleukin-8, all of which may be pathogenic in inflammatory bowel disease. The anti-oxidant activity of aloe vera was assessed in two cell-free, radical-generating systems and by the chemiluminescence of incubated colorectal mucosal biopsies. Eicosanoid production by biopsies and interleukin-8 release by CaCo2 epithelial cells in the presence of aloe vera were measured by enzyme-linked immunosorbent assay. Aloe vera gel had a dose-dependent inhibitory effect on reactive oxygen metabolite production; 50% inhibition occurred at 1 in 1000 dilution in the phycoerythrin assay and at 1 in 10-50 dilution with biopsies. Aloe vera inhibited the production of prostaglandin E2 by 30% at 1 in 50 dilution (P = 0.03), but had no effect on thromboxane B2 production. The release of interleukin-8 by CaCo2 cells fell by 20% (P < 0.05) with aloe vera diluted at 1 in 100, but not at 1 in 10 or 1 in 1000 dilutions. The anti-inflammatory actions of aloe vera gel in vitro provide support for the proposal that it may have a therapeutic effect in inflammatory bowel disease.

                Author and article information

                Dent Res J (Isfahan)
                Dent Res J (Isfahan)
                Dental Research Journal
                Medknow Publications & Media Pvt Ltd (India )
                Jul-Aug 2012
                : 9
                : 4
                : 381-385
                [1 ]Dental Material Research Center, School of Dentistry, Babol University of Medical Sciences, Babol, Iran
                [2 ]Department of Oral Medicine and Diagnosis, School of Dentistry, Babol University of Medical Sciences, Babol, Iran
                [3 ]Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran
                [4 ]Department of Pharmacology and Physiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran
                Author notes
                Address for correspondence: Dr Ebrahim Zabihi, Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Ganje-Afrooz Avenue, Babol, Iran. E-mail: e.zabihi@ 123456mubabol.ac.ir
                Copyright: © Dental Research Journal

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                Original Article

                immunomodulation,aloe vera,aphthous stomatitis,mouth diseases
                immunomodulation, aloe vera, aphthous stomatitis, mouth diseases


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