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      Evaluation of Collagen Gel and Hyaluronic Acid as Vitreous Substitutes

      a , b , c

      Ophthalmic Research

      S. Karger AG

      Vitreous substitute, Collagen gel, Hyaluronic acid

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          We evaluated alkaline-solubilized collagen, hyaluronic acid (HA), and a substance formed from mixing both materials as vitreous substitutes in the rabbit. Fluorescein isothiocyanate (FITC)-labeled collagen (2%), fluorescein-labeled HA (FL-HA, 1%), or the mixture was injected into the rabbit vitreous after vitrectomy. After 3 months, histologic study revealed that the substitutes caused no adverse effects on the ocular tissue. Kinetic studies showed that the half-lives of FITC-collagen, FL-HA, and the mixed substance were 5.70, 2.09, and 8.41 days, respectively. The results indicated that HA enhances the collagen half-life. The concomitant of collagen and HA is safe and effective for 3 months in rabbit’s eye as a vitreous substitute, and the mixture is capable of tamponade.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          11 December 2009
          : 29
          : 6
          : 409-420
          aDepartment of Ophthalmology, Juntendo University, bDepartment of Ophthalmology, Juntendo Urayasu Hospital, cKoken Bioscience Institute, Tokyo, Japan
          268042 Ophthalmic Res 1997;29:409–420
          © 1997 S. Karger AG, Basel

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          Pages: 12
          Original Paper


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