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      Defining valid chronic stress models for depression with female rodents

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      Biological Psychiatry
      Elsevier BV

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          Depression

          Major depression is a common illness that severely limits psychosocial functioning and diminishes quality of life. In 2008, WHO ranked major depression as the third cause of burden of disease worldwide and projected that the disease will rank first by 2030.1 In practice, its detection, diagnosis, and management often pose challenges for clinicians because of its various presentations, unpredictable course and prognosis, and variable response to treatment.
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            Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010

            The Lancet, 382(9904), 1575-1586
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              Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress.

              Mice experiencing repeated aggression develop a long-lasting aversion to social contact, which can be normalized by chronic, but not acute, administration of antidepressant. Using viral-mediated, mesolimbic dopamine pathway-specific knockdown of brain-derived neurotrophic factor (BDNF), we showed that BDNF is required for the development of this experience-dependent social aversion. Gene profiling in the nucleus accumbens indicates that local knockdown of BDNF obliterates most of the effects of repeated aggression on gene expression within this circuit, with similar effects being produced by chronic treatment with antidepressant. These results establish an essential role for BDNF in mediating long-term neural and behavioral plasticity in response to aversive social experiences.
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                Author and article information

                Journal
                Biological Psychiatry
                Biological Psychiatry
                Elsevier BV
                00063223
                March 2021
                March 2021
                Article
                10.1016/j.biopsych.2021.03.010
                33965195
                e6888718-3d52-477e-abf4-1823077452b0
                © 2021

                https://www.elsevier.com/tdm/userlicense/1.0/

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