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      Serum β 2-Microglobulin Levels in Patients Chronically Dialyzed with CA-210 versus CT-190 Dialysis Membranes

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          β<sub>2</sub>-Microglobulin (B<sub>2</sub>M) amyloidosis (dialysis-related amyloidosis), manifested primarily by carpal tunnel syndrome and destructive osteoarthropathy, is a major sequel of long-term dialysis. Previous investigators have shown that high-flux biocompatible synthetic membranes (e.g., polyacrylonitrile) lower β<sub>2</sub>M levels when compared to cellulosic membranes (e.g., cuprophane). To date, however, no study has compared β<sub>2</sub>M levels of patients dialyzed with the two more biocompatible cellulosic membranes CA-210 (cellulose acetate) and CT-190 (cellulose triacetate; high flux, more biocompatible). We retrospectively compared the serum β<sub>2</sub>M levels in two chronic hemodialysis populations: 22 patients on CT-190 and 21 patients on CA-210. There was no difference between the two groups with regard to age, sex, or duration of dialysis. The patients on the CA-210 membrane had significantly higher serum β<sub>2</sub>M levels (mean ± SE; 53.6 ± 4.7 vs. 36.8 ± 2.6 mg/l, CA-210 vs. CT-190, respectively, p = 0.003). Subsequently we switched 13 patients dialyzed with a CA-210 membrane to a CT-190 membrane and followed serum β<sub>2</sub>M levels for 14 months. We found a significant decrease in serum β<sub>2</sub>M levels within 1 month which was maintained over 14 months of follow-up (47.4 ± 4.4 vs. 62.8 ± 6.7 mg/l, CT-190 at 14 months vs. CA-210 at baseline, respectively, p < 0.01).

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          Author and article information

          Am J Nephrol
          American Journal of Nephrology
          S. Karger AG
          February 1998
          16 January 1998
          : 18
          : 1
          : 16-20
          Division of Nephrology, St. Louis University Health Sciences Center, St. Louis, Mo., USA
          13299 Am J Nephrol 1998;18:16–20
          © 1998 S. Karger AG, Basel

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          Page count
          Figures: 3, Tables: 1, References: 27, Pages: 5
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          Clinical Study

          Cardiovascular Medicine, Nephrology

          Hemodialysis, Amyloid, β2-Microglobulin, Osteodystrophy


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