Clinico-pathological correlation of E-cadherin expression at the invasive tumor front of Indian oral squamous cell carcinomas: An immunohistochemical study

Abstract

Background:

Recent studies have indicated that although malignant cells at the invasive tumor front, bare morphological resemblance to the cells at central portion of the tumor, their molecular character differs significantly. E-cadherin is a cell-cell adhesion molecule that connects epithelial cells. This study attempts to correlate the E-cadherin expression at the invasive tumor front with tumor differentiation along with its clinico-pathological parameters.

Materials and Methods:

Immunohistochemical staining with E-cadherin was carried out on archival cases of primary oral squamous cell carcinomas ( n = 30). The E-cadherin expression at the invasive tumor front was analyzed and was linked to clinico-pathological parameters including patient prognosis.

Results:

The downregulation of E-cadherin expression at the invasive tumor edge when compared with patient's prognosis yielded a significant correlation ( P = 0.041) but its correlation with the degree of differentiation determined was not significant ( P = 0.27). Also, its association with tumor size and lymph node status was negative.

Conclusions:

Loss of E-cadherin expression at the invasive tumor front is an important event in the progression of oral squamous cell carcinomas. Tumors with a loss of expression of E-cadherin are those which had a poor prognosis