+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Correlation between higher serum uric acid and glycolipid metabolism in college students


      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Objective To explore the epidemiological characteristics of elevated serum uric acid in college students and its association with glycolipid metabolism, providing reference for health care intervention and education of college students.

          Methods From September 2020 to November 2021, a retrospective study was conducted among 989 college students in Taizhou area by stratified cluster random sampling method, and a questionnaire was issued to all college students. Serum uric acid (SUA), high density lipoprotein (HDL), low density lipoprotein (LDL), fasting plasma glucose(FPG), 2 h postprandial blood glucose (2 hPG), total cholesterol (TC), triglyceride (TG) levels were detected by urease immunoassay and enzyme-linked immunosorbent assay.

          Results Waist circumference, body mass index, systolic blood pressure and diastolic blood pressure in higher serum uric acid group were higher than those in normal group ( t=21.72, 5.74, 5.45, 12.23, P<0.05). The SUA, FPG, TG, 2 hPG, LDL and TC in serum uric acid increased group were higher than those in normal group, while HDL was lower than those in normal group ( t=13.85, 23.97, 10.24, 7.62, 34.91, 8.27, −8.15, P<0.05). Pearson correlation analysis showed that the levels of FPG, TG, 2 hPG, LDL and TC were positively correlated with SUA levels ( r=0.63, 0.72, 0.69, 0.16, 0.81, P<0.01). HDL was negatively correlated with SUA level ( r=−0.52, P<0.01). The glucolipid metabolism indexes were included into the binary Logistic regression model analysis, and the results showed that FPG, TG, LDL and TC were positively correlated with higher serum uric acid. HDL was negatively correlated with the incidence of higher serum uric acid ( P<0.05).

          Conclusion Male sex, alcohol consumption, smoking, and elevated blood pressure can contribute to higher serum uric acid, which has been found to be associated with glycolipid metabolism.


          【摘要】 目的 探究大学生血尿酸增髙流行病学特征及其与糖脂代谢相关性, 为髙校学生保健相关干预与教育提供参 考。 方法 采用分层整群随机抽样法于 2020 年 9 月 一2021 年 11 月选取台州市 2 所髙校 989 名大学生进行调査。分别采 用尿素酶免疫法、酶联免疫吸附法检测受检者血尿酸 (SUA)、髙密度脂蛋白 (HDL)、低密度脂蛋白 (LDL)、空腹血糖 (FPG)、餐后 2 h 血糖 (2 hPG)、总胆固醇 (TC)、三酰甘油 (TG) 水平。 结果 大学生血尿酸增髙组腰围、体质量指数、收缩 压、舒张压均髙于正常组 ( t 值分别为 21.72, 5.74, 5.45, 12.23, P 值均<0.05); 血尿酸增髙组 SUA、FPG、TG、2 hPG、LDL、TC 均髙于正常组, HDL 低于正常组 ( t 值分别为 29.40, 23.97, 10.24, 7.62, 34.91, 8.27, −8.15, P 值均<0.05)。Pearson 相关分析 发现, SUA 水平与 FPG、TG、2 hPG、LDL、TC 水平均呈正相关, 与 HDL 呈负相关 ( r 值分别为 0.63, 0.72, 0.69, 0.16, 0.81, −0.52, P 值均<0.01)。将糖脂代谢指标纳人二分类多因素 Logistic 回归模型, 结果显示, FPG、TG、LDL、TC与血尿酸增髙发 生均呈正相关, HDL与血尿酸增髙发生呈负相关 ( P 值均<0.05)。 结论 男性、饮酒、抽烟、血压上升易发生血尿酸增髙, 血尿酸增髙的发生与糖脂代谢有相关性。

          Related collections

          Author and article information

          Chinese Journal of School Health
          Chinese Journal of School Health (China )
          01 April 2022
          01 April 2022
          : 43
          : 4
          : 610-613
          [1] 1Nursing Department, Taizhou Central Hospital (Affiliated Hospital of Taizhou University), Taizhou (318000), Zhejiang Province, China
          © 2022 Chinese Journal of School Health

          This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (CC BY-NC 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc/4.0/.

          Self URI (journal-page): http://www.cjsh.org.cn
          Journal Article

          Ophthalmology & Optometry,Pediatrics,Nutrition & Dietetics,Clinical Psychology & Psychiatry,Public health
          Glucose,Adipose tissue,Metabolism,Regression analysis,Students,Uric Acid


          Comment on this article