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      Research resources: curating the new eagle-i discovery system

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          Abstract

          Development of biocuration processes and guidelines for new data types or projects is a challenging task. Each project finds its way toward defining annotation standards and ensuring data consistency with varying degrees of planning and different tools to support and/or report on consistency. Further, this process may be data type specific even within the context of a single project. This article describes our experiences with eagle-i, a 2-year pilot project to develop a federated network of data repositories in which unpublished, unshared or otherwise ‘invisible’ scientific resources could be inventoried and made accessible to the scientific community. During the course of eagle-i development, the main challenges we experienced related to the difficulty of collecting and curating data while the system and the data model were simultaneously built, and a deficiency and diversity of data management strategies in the laboratories from which the source data was obtained. We discuss our approach to biocuration and the importance of improving information management strategies to the research process, specifically with regard to the inventorying and usage of research resources. Finally, we highlight the commonalities and differences between eagle-i and similar efforts with the hope that our lessons learned will assist other biocuration endeavors.

          Database URL: www.eagle-i.net

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          Most cited references21

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          Big data: The future of biocuration.

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            The Immune Epitope Database and Analysis Resource: From Vision to Blueprint

            A planned repository of immune epitope data with associated analysis tools should be a boon to vaccine development
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              Bio-ontologies: current trends and future directions.

              In recent years, as a knowledge-based discipline, bioinformatics has been made more computationally amenable. After its beginnings as a technology advocated by computer scientists to overcome problems of heterogeneity, ontology has been taken up by biologists themselves as a means to consistently annotate features from genotype to phenotype. In medical informatics, artifacts called ontologies have been used for a longer period of time to produce controlled lexicons for coding schemes. In this article, we review the current position in ontologies and how they have become institutionalized within biomedicine. As the field has matured, the much older philosophical aspects of ontology have come into play. With this and the institutionalization of ontology has come greater formality. We review this trend and what benefits it might bring to ontologies and their use within biomedicine.
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                Author and article information

                Journal
                Database (Oxford)
                databa
                databa
                Database: The Journal of Biological Databases and Curation
                Oxford University Press
                1758-0463
                2012
                13 February 2012
                13 February 2012
                : 2012
                : bar067
                Affiliations
                1Oregon Health & Science University, Library, LIB, 3181 S.W. Sam Jackson Park Rd., Portland, OR 97239-3098 and 2Harvard Medical School, Center for Biomedical Informatics, One Kendall Square, Suite B6303, Boston, MA 02139, USA
                Author notes
                * Corresponding author: Tel: +503-407-5970; Fax: +503-494-3322; Email: haendel@ 123456ohsu.edu
                Article
                bar067
                10.1093/database/bar067
                3308157
                22434835
                e6dd0e18-c484-4d36-be00-9addff08737e
                © The Author(s) 2012. Published by Oxford University Press.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 3 October 2011
                : 12 December 2011
                : 13 December 2011
                Page count
                Pages: 13
                Categories
                Original Articles

                Bioinformatics & Computational biology
                Bioinformatics & Computational biology

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