Mutant Hras(G12V)  and Kras(G12D)  have overlapping, but non-identical effects on hepatocyte growth and transformation frequency in transgenic mice.

Figueiredo, Marxa L.; Stein, Timothy J.; Jochem, Adam; Sandgren, Eric P

doi:10.1111/j.1478-3231.2011.02732.x

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Mutant Hras(G12V) and Kras(G12D) have overlapping, but non-identical effects on hepatocyte growth and transformation frequency in transgenic mice.

Author(s): Marxa L Figueiredo ¹ , Timothy J Stein , Adam Jochem , Eric P Sandgren

Publication date (Electronic): Apr 2012

Journal: Liver international : official journal of the International Association for the Study of the Liver

Publisher: Wiley

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Abstract

Mouse hepatocarcinogenesis is associated with mutations in Hras, but infrequently in Kras. The effect on carcinogenesis of developmental age at the time of ras mutation remains unknown.

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Journal

Journal ID (iso-abbrev): Liver Int.

Title: Liver international : official journal of the International Association for the Study of the Liver

Publisher: Wiley

ISSN (Electronic): 1478-3231

ISSN (Print): 1478-3223

Publication date (Electronic): Apr 2012

Volume: 32

Issue: 4

Affiliations

[1 ] Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.

Article

Mid ID: NIHMS343091

DOI: 10.1111/j.1478-3231.2011.02732.x

PMC ID: 4319543

PubMed ID: 22221894

SO-VID: e6e4963e-9305-4a0f-abbd-50cb18a4cb0b

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