354
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The impact of next-generation sequencing technology on genetics.

      1
      Trends in genetics : TIG
      Elsevier BV

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          If one accepts that the fundamental pursuit of genetics is to determine the genotypes that explain phenotypes, the meteoric increase of DNA sequence information applied toward that pursuit has nowhere to go but up. The recent introduction of instruments capable of producing millions of DNA sequence reads in a single run is rapidly changing the landscape of genetics, providing the ability to answer questions with heretofore unimaginable speed. These technologies will provide an inexpensive, genome-wide sequence readout as an endpoint to applications ranging from chromatin immunoprecipitation, mutation mapping and polymorphism discovery to noncoding RNA discovery. Here I survey next-generation sequencing technologies and consider how they can provide a more complete picture of how the genome shapes the organism.

          Related collections

          Author and article information

          Journal
          Trends Genet
          Trends in genetics : TIG
          Elsevier BV
          0168-9525
          0168-9525
          Mar 2008
          : 24
          : 3
          Affiliations
          [1 ] Genome Sequencing Center, Washington University School of Medicine, St. Louis, MO 63108, USA. emardis@watson.wustl.edu
          Article
          S0168-9525(08)00023-1
          10.1016/j.tig.2007.12.007
          18262675
          e6e7bb92-e2b5-416e-818f-dbbf6ea8f48c

          Comments

          Comment on this article