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      Electropharmacologic Characteristics and Radiof requency Catheter Ablation of Sustained Ventricular Tachycardia in Patients without Structural Heart Disease


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          Twenty-six patients (mean age 39 ± 17 years) with idiopathic sustained ventricular tachycardia (VT) were included for study. The patients were divided into two groups: group I: 14 patients with VT originating from the right ventricular outflow tract (wide QRS tachycardia with complete left bundle branch block pattern), and group II: 12 patients with VT originating from the left ventricle (wide QRS tachycardia with complete right bundle branch block pattern). Most of the group I patients (11/14) needed isoproterenol to facilitate induction of VT, and were sensitive to both verapamil and adenosine. Eight patients had successful radiofrequency (RF) ablation and were free of VT without any antiarrhythmic drugs. In group II, sustained VT was induced by programmed ventricular stimulation in all the patients (only 3 patients needed isoproterenol for facilitation); verapamil could terminate all the VT but none of the patients responded to adenosine. Eight patients received RF ablation and 6 patients had successful ablation without recurrent tachycardia on a long-term basis. Different sensitivity to adenosine and isoproterenol between right and left ventricular idiopathic VT suggested different underlying mechanisms for both types of VT. The patients who did not receive catheter ablation still had attacks of VT despite antiarrhythmic drug treatment; however, none of these patients had sudden death since the first attack of VT (mean 95 ± 51 months), suggesting a benign prognosis in idiopathic VT.

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          Author and article information

          S. Karger AG
          19 November 2008
          : 87
          : 1
          : 33-41
          Division of Cardiology, Department of Medicine, National Yang-Ming University School of Medicine, and Veterans General Hospital-Taipei and Kaohsiung, Taiwan, ROC
          177057 Cardiology 1996;87:33–41
          © 1996 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 30 December 1994
          : 27 March 1995
          Page count
          Pages: 9
          Arrhythmias, Electrophysiology and Electrocardiography

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Ventricular tachycardia, idiopathic,Antiarrhythmic drugs,Radiofrequency ablation


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