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      Limited sampling strategy for estimating individual exposure of tacrolimus in pediatric kidney transplant patients.

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          Abstract

          Limited sampling strategies (LSS) for estimating the area under the curve (AUC(0-12h)) of tacrolimus and optimizing dosage adjustment are not currently used or fully validated in pediatric patients, although the method is of real benefit to children. The objective of the present study was to develop and validate reliable and clinically applicable LSS using Bayesian estimation and the multiple regression analysis for estimating tacrolimus AUC in pediatric kidney transplant patients.

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          Author and article information

          Journal
          Ther Drug Monit
          Therapeutic drug monitoring
          Ovid Technologies (Wolters Kluwer Health)
          1536-3694
          0163-4356
          Dec 2011
          : 33
          : 6
          Affiliations
          [1 ] Department of Pediatric Pharmacology and Pharmacogenetics, Hôpital Robert Debré, Assistance Publique-Hôpitaux de Paris, Université Paris VII, Paris, France.
          Article
          10.1097/FTD.0b013e318235d067
          22011724
          e6eee8c0-87c7-42f4-b49d-92e7566c9db5
          History

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