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      International Journal of Nanomedicine (submit here)

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      Effect of compositions in nanostructured lipid carriers (NLC) on skin hydration and occlusion

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          Abstract

          Purpose

          To study the effects of varying lipid concentrations, lipid and oil ratio, and the addition of propylene glycol and lecithin on the long-term physical stability of nanostructured lipid nanocarriers (NLC), skin hydration, and transepidermal water loss.

          Methods

          The various NLC formulations (A1–A5) were prepared and their particle size, zeta potential, viscosity, and stability were analyzed. The formulations were applied on the forearms of the 20 female volunteers (one forearm of each volunteer was left untreated as a control). The subjects stayed for 30 minutes in a conditioned room with their forearms uncovered to let the skin adapt to the temperature (22°C ± 2°C) and humidity (50% ± 2%) of the room. Skin hydration and skin occlusion were recorded at day one (before treatment) and day seven (after treatment). Three measurements for skin hydration and skin occlusion were performed in each testing area.

          Results

          NLC formulations with the highest lipid concentration, highest solid lipid concentration, and additional propylene glycol (formulations A1, A2, and A5) showed higher physical stability than other formulations. The addition of propylene glycol into an NLC system helped to reduce the particle size of the NLC and enhanced its long-term physical stability. All the NLC formulations were found to significantly increase skin hydration compared to the untreated controls within 7 days. All NLC formulations exhibited occlusive properties as they reduced the transepidermal water loss within 7 days. This effect was more pronounced with the addition of propylene glycol or lecithin into an NLC formulation, whereby at least 60% reduction in transepidermal water loss was observed.

          Conclusion

          NLCs with high lipid content, solid lipid content, phospholipid, and lecithin are a highly effective cosmetic delivery system for cosmetic topical applications that are designed to boost skin hydration.

          Author and article information

          Journal
          Int J Nanomedicine
          Int J Nanomedicine
          International Journal of Nanomedicine
          Dove Medical Press
          1176-9114
          1178-2013
          2013
          2013
          27 December 2012
          : 8
          : 13-22
          Affiliations
          [1 ]Malaysian Palm Oil Board, Bandar Baru Bangi, Serdang
          [2 ]Department of Chemistry, Universiti Putra Malaysia, Serdang
          [3 ]Department of Molecular Medicine, University of Malaya, Kuala Lumpur, Malaysia
          Author notes
          Correspondence: Mahiran Basri, Department of Chemistry, University Putra, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia, Tel +603 8925 5708, Fax +603 8925 6197, Email mahiran@ 123456science.upm.edu.my
          Article
          ijn-8-013
          10.2147/IJN.S35648
          3534299
          23293516
          e6f0e095-62e0-4277-9a9f-a8f2fd3f00d2
          © 2013 Loo et al, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

          History
          Categories
          Original Research

          Molecular medicine
          nanostructured lipid carriers,particle size,skin hydration,transepidermal water loss

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