Myocardial Calcium in Experimental Myocardial Infarction

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Abstract

Significant increases in myocardial calcium and sodium concentrations and decreases in magnesium and potassium concentrations were observed in infarcted myocardium 5 days after injury when compared against normal myocardium from the same animals. Intermediate changes were observed in periinfarct tissues. Even apparently normal myocardium from infarcted animals showed these same changes when compared against normal myocardium from animals without infarction. <sup>45</sup>Ca uptake into intact myocardium and specifically the mitochondrial fraction were still increased more than threefold during the 24-hour period prior to sacrifice on the fifth postinfarction day. Myocardial calcium appears to be in a readily exchangeable equilibrium with circulating serum calcium even in this late stage in the evolution of the infarction.

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Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1974

Publication date (Print): 1974

Publication date (Electronic): 29 October 2008

Volume: 59

Issue: 6

Pages: 367-375

Affiliations

Medical Service, Oklahoma City Veterans Administration Hospital and Departments of Medicine and Physiology, University of Oklahoma College of Medicine, Oklahoma City, Okla.

Article

Publisher ID: 169695 Other ID: Cardiology 1974;59:367–375

DOI: 10.1159/000169695

PubMed ID: 4469790

SO-VID: e6fcb5d7-12a3-4ae4-b5f5-76f44abbaa8e

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Myocardial Calcium in Experimental Myocardial Infarction

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Karger: Cardiovascular System

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