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      Myocardial Calcium in Experimental Myocardial Infarction

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          Abstract

          Significant increases in myocardial calcium and sodium concentrations and decreases in magnesium and potassium concentrations were observed in infarcted myocardium 5 days after injury when compared against normal myocardium from the same animals. Intermediate changes were observed in periinfarct tissues. Even apparently normal myocardium from infarcted animals showed these same changes when compared against normal myocardium from animals without infarction. <sup>45</sup>Ca uptake into intact myocardium and specifically the mitochondrial fraction were still increased more than threefold during the 24-hour period prior to sacrifice on the fifth postinfarction day. Myocardial calcium appears to be in a readily exchangeable equilibrium with circulating serum calcium even in this late stage in the evolution of the infarction.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1974
          1974
          29 October 2008
          : 59
          : 6
          : 367-375
          Affiliations
          Medical Service, Oklahoma City Veterans Administration Hospital and Departments of Medicine and Physiology, University of Oklahoma College of Medicine, Oklahoma City, Okla.
          Article
          169695 Cardiology 1974;59:367–375
          10.1159/000169695
          4469790
          © 1974 S. Karger AG, Basel

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          Pages: 9
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