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      Reactive oxygen species in inflammation and tissue injury.

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          Abstract

          Abstract Reactive oxygen species (ROS) are key signaling molecules that play an important role in the progression of inflammatory disorders. An enhanced ROS generation by polymorphonuclear neutrophils (PMNs) at the site of inflammation causes endothelial dysfunction and tissue injury. The vascular endothelium plays an important role in passage of macromolecules and inflammatory cells from the blood to tissue. Under the inflammatory conditions, oxidative stress produced by PMNs leads to the opening of inter-endothelial junctions and promotes the migration of inflammatory cells across the endothelial barrier. The migrated inflammatory cells not only help in the clearance of pathogens and foreign particles but also lead to tissue injury. The current review compiles the past and current research in the area of inflammation with particular emphasis on oxidative stress-mediated signaling mechanisms that are involved in inflammation and tissue injury.

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          Author and article information

          Journal
          Antioxid Redox Signal
          Antioxidants & redox signaling
          Mary Ann Liebert Inc
          1557-7716
          1523-0864
          Mar 01 2014
          : 20
          : 7
          Affiliations
          [1 ] 1 Department of Pharmacology, Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, Illinois.
          Article
          10.1089/ars.2012.5149
          3929010
          23991888
          e70fcc10-06f5-4220-947c-cb591d653ba0
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