Scopariusols L–T, nine new  ent -kaurane diterpenoids isolated from  Isodon scoparius

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Abstract

Nine new ent-kaurane diterpenoids, named scopariusols L–T ( 1–9), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC ₅₀ value of 0.6 μmol·L ^–1.

Author and article information

Journal

Journal ID (publisher-id): CJNM

Title: Chinese Journal of Natural Medicines

Publisher: Elsevier

ISSN (Electronic): 1875-5364

Publication date (Electronic): 20 June 2018

Volume: 16

Issue: 6

Pages: 456-464

Affiliations

[1] ¹Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China

[2] ²State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

[3] ³University of Chinese Academy of Sciences, Beijing 100049, China

Author notes

*Corresponding author: ZHANG Hong-Bin, E-mails: zhanghb@ 123456ynu.edu.cn ; PUNO Pema-Tenzin, punopematenzin@ 123456mail.kib.ac.cn

These authors have no conflict of interest to declare.

Article

Publisher ID: S1875-5364(18)30079-7

DOI: 10.1016/S1875-5364(18)30079-7

SO-VID: e7283b32-0651-46dc-b9b2-605ac59a8639

History

Date received : 12 December 2017

Funding

Funded by: National Natural Science Foundation of China

Award ID: 21322204

Funded by: NSFC-Joint Foundation of Yunnan Province

Award ID: U1302223

This work was supported by the National Natural Science Foundation of China (No. 21322204), and the NSFC-Joint Foundation of Yunnan Province (No. U1302223).

ScienceOpen disciplines: Medicine,Pharmaceutical chemistry,Pharmacology & Pharmaceutical medicine,Complementary & Alternative medicine

Keywords: X-ray diffraction,Cytotoxicity,Anti-inflammatory activity, Isodon scoparius , Ent-kaurane diterpenoids

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ScienceOpen disciplines: Medicine, Pharmaceutical chemistry, Pharmacology & Pharmaceutical medicine, Complementary & Alternative medicine

Keywords: X-ray diffraction, Cytotoxicity, Anti-inflammatory activity, Isodon scoparius , Ent-kaurane diterpenoids