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      Scopariusols L–T, nine new ent-kaurane diterpenoids isolated from Isodon scoparius

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          Abstract

          Nine new ent-kaurane diterpenoids, named scopariusols L–T ( 1–9), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC 50 value of 0.6 μmol·L –1.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 June 2018
          : 16
          : 6
          : 456-464
          Affiliations
          1Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
          2State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
          3University of Chinese Academy of Sciences, Beijing 100049, China
          Author notes
          *Corresponding author: ZHANG Hong-Bin, E-mails: zhanghb@ 123456ynu.edu.cn ; PUNO Pema-Tenzin, punopematenzin@ 123456mail.kib.ac.cn

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(18)30079-7
          10.1016/S1875-5364(18)30079-7
          Copyright © 2018 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: 21322204
          Funded by: NSFC-Joint Foundation of Yunnan Province
          Award ID: U1302223
          This work was supported by the National Natural Science Foundation of China (No. 21322204), and the NSFC-Joint Foundation of Yunnan Province (No. U1302223).

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