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      Predicting chronic copper and nickel reproductive toxicity to Daphnia pulex-pulicaria from whole-animal metabolic profiles.

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          Abstract

          The emergence of omics approaches in environmental research has enhanced our understanding of the mechanisms underlying toxicity; however, extrapolation from molecular effects to whole-organism and population level outcomes remains a considerable challenge. Using environmentally relevant, sublethal, concentrations of two metals (Cu and Ni), both singly and in binary mixtures, we integrated data from traditional chronic, partial life-cycle toxicity testing and metabolomics to generate a statistical model that was predictive of reproductive impairment in a Daphnia pulex-pulicaria hybrid that was isolated from an historically metal-stressed lake. Furthermore, we determined that the metabolic profiles of organisms exposed in a separate acute assay were also predictive of impaired reproduction following metal exposure. Thus we were able to directly associate molecular profiles to a key population response - reproduction, a key step towards improving environmental risk assessment and management.

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          Author and article information

          Journal
          Environ. Pollut.
          Environmental pollution (Barking, Essex : 1987)
          Elsevier BV
          1873-6424
          0269-7491
          May 2016
          : 212
          Affiliations
          [1 ] Biology Department, Wilfrid Laurier University, 75 University Avenue West, Waterloo, ON, N2L 3C5, Canada; Vale Living with Lakes Centre, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON, P3E 2C6, Canada. Electronic address: n.s.taylor@bham.ac.uk.
          [2 ] School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
          [3 ] Biology Department, Wilfrid Laurier University, 75 University Avenue West, Waterloo, ON, N2L 3C5, Canada.
          [4 ] Department of Biology, York University, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada.
          [5 ] Vale Living with Lakes Centre, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON, P3E 2C6, Canada.
          Article
          S0269-7491(16)30074-4
          10.1016/j.envpol.2016.01.074
          26854702
          e72e4116-7140-464f-a66e-e67841ca9a1a
          History

          Metal mixtures,Environmental risk assessment,Mass spectrometry,Metabolomics,PLS-R,Ecotoxicology

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