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      Addition of ulinastatin to preservation solution promotes protection against ischemia-reperfusion injury in rabbit lung.

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          Abstract

          The composition of the lung preservation solution used in lung graft procurement has been considered the key to minimize lung injury during the period of ischemia. Low-potassium dextran glucose (LPDG), an extracellular-type solution, has been adopted by most lung transplantation centers, due to the experimental and clinical evidences that LPDG is superior to intracellular-type solutions. Ulinastatin has been shown to attenuate ischemia-reperfusion (I/R) injury in various organs in animals. We supposed that the addition of ulinastatin to LPDG as a flushing solution, would further ameliorate I/R lung injury than LPDG solution alone.

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          Author and article information

          Journal
          Chin. Med. J.
          Chinese medical journal
          0366-6999
          0366-6999
          Jul 2011
          : 124
          : 14
          Affiliations
          [1 ] Department of Anesthesiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.
          Article
          21933623
          e737ee6b-20e0-4d34-b294-f1aaa2595996
          History

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