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      Effect of Inhibitors of Neuronal and Extraneuronal Uptake on the Accumulation and Metabolism of 3H- l-Norepinephrine in Rabbit Aorta

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          Abstract

          In the isolated adventitia of rabbit aorta, blockade of neuronal uptake decreased the accumulation and deamination of <sup>3</sup>H-/-norepinephrine (<sup>3</sup>H- l-NE) whereas blockade of extraneuronal uptake decreased O-methylation. Thus most of the O-methylation occurs in the extraneuronal elements. In the isolated media, blockade of extraneuronal uptake decreased metabolism but not accumulation of <sup>3</sup>H- l-NE. If NE metabolism was prevented by pretreatment with pargyline and U-0521, <sup>3</sup>H- l-NE accumulation in the isolated media increased markedly and now inhibitors of extraneuronal uptake could decrease this accumulation of <sup>3</sup>H- l-NE by the isolated media. Thus when MAO and COMT are intact, NE does not accumulate in the extraneuronal compartment containing these enzymes, probably because it is metabolized as fast as it enters the compartment. Since the level of <sup>3</sup>H- l-NE in the isolated media exceeded the sorbitol space when MAO and COMT were intact, some <sup>3</sup>H- l-NE must have accumulated in a compartment which does not contain these enzymes.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1983
          1983
          19 September 2008
          : 20
          : 5
          : 234-244
          Affiliations
          Department of Pharmacology and Therapeutics, Medical College of Ohio, Toledo, Ohio, USA
          Article
          158476 Blood Vessels 1983;20:234–244
          10.1159/000158476
          © 1983 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 11
          Categories
          Research Paper

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