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      The heat shock response: life on the verge of death.

      1 , ,

      Molecular cell

      Elsevier BV

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          Abstract

          Organisms must survive a variety of stressful conditions, including sudden temperature increases that damage important cellular structures and interfere with essential functions. In response to heat stress, cells activate an ancient signaling pathway leading to the transient expression of heat shock or heat stress proteins (Hsps). Hsps exhibit sophisticated protection mechanisms, and the most conserved Hsps are molecular chaperones that prevent the formation of nonspecific protein aggregates and assist proteins in the acquisition of their native structures. In this Review, we summarize the concepts of the protective Hsp network.

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          Author and article information

          Journal
          Mol Cell
          Molecular cell
          Elsevier BV
          1097-4164
          1097-2765
          Oct 22 2010
          : 40
          : 2
          Affiliations
          [1 ] Munich Center for Integrated Protein Science, Department Chemie Technische Universität München, 85747 Garching, Germany.
          Article
          S1097-2765(10)00782-3
          10.1016/j.molcel.2010.10.006
          20965420
          e755fa0d-a51d-473a-89bb-1af31cfe8254
          Copyright © 2010 Elsevier Inc. All rights reserved.

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