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      Induction of tumor necrosis factor-α mRNA in the brain after peripheral endotoxin treatment: comparison with interleukin-1 family and interleukin-6

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      Brain Research
      Elsevier BV

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          Abstract

          The constitutive expression of tumor necrosis factor-alpha (TNF alpha) mRNA and its induction (60 min later) by peripheral injection of Escherichia coli lipopolysaccharide (2 mg/kg i.p.) was demonstrated by polymerase chain reaction (PCR), in the pituitary and hypothalamus but not in the striatum or hippocampus of the rat. The pattern of TNF alpha mRNA induction is different from that observed for mRNAs of IL-1 alpha and IL-1 beta, IL-1ra and IL-6 respectively. This demonstration of the induction of TNF alpha in the brain may contribute to our understanding of the central effects of TNF alpha in fever and anorexia.

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          Author and article information

          Journal
          Brain Research
          Brain Research
          Elsevier BV
          00068993
          October 1993
          October 1993
          : 624
          : 1-2
          : 291-294
          Article
          10.1016/0006-8993(93)90090-A
          8252403
          e75f6e2d-072b-4ea0-a240-7cc9d2f63fc3
          © 1993

          https://www.elsevier.com/tdm/userlicense/1.0/

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