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      ESMO Management and treatment adapted recommendations in the COVID-19 era: Lung cancer

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          Abstract

          The COVID-19 pandemic, characterised by a fast and global spread during the first months of 2020, has prompted the development of a structured set of recommendations for cancer care management, to maintain the highest possible standards. Within this framework, it is crucial to ensure no disruption to essential oncological services and guarantee the optimal care.

          This is a structured proposal for the management of lung cancer, comprising three levels of priorities, namely: tier 1 (high priority), tier 2 (medium priority) and tier 3 (low priority)—defined according to the criteria of the Cancer Care Ontario, Huntsman Cancer Institute and Magnitude of Clinical Benefit Scale.

          The manuscript emphasises the impact of the COVID-19 pandemic on lung cancer care and reconsiders all steps from diagnosis, staging and treatment.

          These recommendations should, therefore, serve as guidance for prioritising the different aspects of cancer care to mitigate the possible negative impact of the COVID-19 pandemic on the management of our patients.

          As the situation is rapidly evolving, practical actions are required to guarantee the best patients’ treatment while protecting and respecting their rights, safety and well-being. In this environment, cancer practitioners have great responsibilities: provide timely, appropriate, compassionate and justified cancer care, while protecting themselves and their patients from being infected with COVID-19. In case of shortages, resources must be distributed fairly. Consequently, the following recommendations can be applied with significant nuances, depending on the time and location for their use, considering variable constraints imposed to the health systems. An exceptional flexibility is required from cancer caregivers.

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          Clinical Characteristics of Coronavirus Disease 2019 in China

          Abstract Background Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients. Methods We extracted data regarding 1099 patients with laboratory-confirmed Covid-19 from 552 hospitals in 30 provinces, autonomous regions, and municipalities in mainland China through January 29, 2020. The primary composite end point was admission to an intensive care unit (ICU), the use of mechanical ventilation, or death. Results The median age of the patients was 47 years; 41.9% of the patients were female. The primary composite end point occurred in 67 patients (6.1%), including 5.0% who were admitted to the ICU, 2.3% who underwent invasive mechanical ventilation, and 1.4% who died. Only 1.9% of the patients had a history of direct contact with wildlife. Among nonresidents of Wuhan, 72.3% had contact with residents of Wuhan, including 31.3% who had visited the city. The most common symptoms were fever (43.8% on admission and 88.7% during hospitalization) and cough (67.8%). Diarrhea was uncommon (3.8%). The median incubation period was 4 days (interquartile range, 2 to 7). On admission, ground-glass opacity was the most common radiologic finding on chest computed tomography (CT) (56.4%). No radiographic or CT abnormality was found in 157 of 877 patients (17.9%) with nonsevere disease and in 5 of 173 patients (2.9%) with severe disease. Lymphocytopenia was present in 83.2% of the patients on admission. Conclusions During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness. Patients often presented without fever, and many did not have abnormal radiologic findings. (Funded by the National Health Commission of China and others.)
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            Fair Allocation of Scarce Medical Resources in the Time of Covid-19

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              SARS-CoV-2 Transmission in Patients With Cancer at a Tertiary Care Hospital in Wuhan, China

              This cross-sectional study reviews the medical records of 1524 patients with cancer treated at a single tertiary care hospital in Wuhan, China, to evaluate the characteristics associated with transmission of the SARS-CoV-2 virus.
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                Author and article information

                Journal
                ESMO Open
                ESMO Open
                esmoopen
                esmoopen
                ESMO Open
                BMJ Publishing Group (BMA House, Tavistock Square, London, WC1H 9JR )
                2059-7029
                2020
                23 June 2020
                23 June 2020
                : 5
                : Suppl 3
                : e000820
                Affiliations
                [1 ]departmentDivision of Thoracic Oncology , European Institute of Oncology, IRCCS , Milan, Italy
                [2 ]University Hospital of Geneva Department of Oncology , Geneva, Switzerland
                [3 ]departmentDepartment of Pulmonary Medicine , Centre Hospitalier Universitaire Vaudois (CHUV) , Lausanne, Switzerland
                [4 ]departmentDivision of Cancer Sciences , University of Manchester & The Christie NHS Foundation Trust , Manchester, UK
                [5 ]departmentDepartment of Medical Oncology, Thoracic Unit , Gustave Roussy , Villejuif, France
                [6 ]Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO) , Barcelona, Spain
                [7 ]departmentDepartment of Oncology and Radiotherapy , Gdanski Uniwersytet Medyczny , Gdansk, Poland
                [8 ]LungenClinic, Airway Research Center North, German Center for Lung Research , Grosshansdorf, Germany
                [9 ]departmentDepartment of Oncology , Centre Hospitalier Universitaire Vaudois (CHUV) , Lausanne, Switzerland
                Author notes
                [Correspondence to ] Dr Antonio Passaro; Antonio.Passaro@ 123456ieo.it
                Author information
                http://orcid.org/0000-0002-7575-3870
                http://orcid.org/0000-0003-0988-0828
                Article
                esmoopen-2020-000820
                10.1136/esmoopen-2020-000820
                7319703
                32581069
                e7633261-2d83-41fb-ba09-7a021a31dde0
                © Author (s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ on behalf of the European Society for Medical Oncology.

                This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, any changes made are indicated, and the use is non-commercial. See:  http://creativecommons.org/licenses/by-nc/4.0/.

                History
                : 05 May 2020
                : 20 May 2020
                : 20 May 2020
                Categories
                Original Research
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                lung cancer,covid19,sars-cov-2
                lung cancer, covid19, sars-cov-2

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