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      Dolutegravir 50 mg thrice weekly plus atazanavir 400 mg daily in a long-term virologically suppressed HIV-infected patient.

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          Abstract

          Highly active antiretroviral therapy (HAART) has changed the natural course of HIV infection. However, the toxicities associated with long-term use of nucleoside reverse transcriptase inhibitors (NRTIs) have led to the assessment of dual-therapy approaches with less toxicity. Atazanavir and dolutegravir have antiviral potency, tolerability and favourable metabolic profile. In suppressed HIV-infected patients, with NRTIs-related toxicity effects, the association of atazanavir and dolutegravir, favoured by their positive pharmacokinetics interaction, could be used as 'maintenance' antiretroviral therapy. We report a case report about one HIV-infected patient, on HAART and with a persistent suppression of HIV RNA, switched to dolutegravir 50 mg three times weekly plus atazanavir 400 mg once daily, as 'maintenance antiretroviral therapy', with persistence of viral suppression.

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          Author and article information

          Journal
          Int J STD AIDS
          International journal of STD & AIDS
          SAGE Publications
          1758-1052
          0956-4624
          Jun 2017
          : 28
          : 7
          Affiliations
          [1 ] 1 Infectious Diseases Unit, G.B. Rossi University Hospital, Verona, Italy.
          [2 ] 2 Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan.
          Article
          0956462416678164
          10.1177/0956462416678164
          27789848
          e76f1bd1-e6ba-4e05-8bd7-740511dd6ff4
          History

          Atazanavir,dolutegravir,maintenance antiretroviral therapy,pharmacokinetics

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