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      HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report.

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          Abstract

          Durable HIV-1 remission after interruption of combined antiretroviral therapy (ART) has been reported in some adults who started treatment during primary infection; however, whether long-term remission in vertically infected children is possible was unknown. We report a case of a young adult perinatally infected with HIV-1 with viral remission despite long-term treatment interruption.

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          Author and article information

          Journal
          Lancet HIV
          The lancet. HIV
          Elsevier BV
          2352-3018
          2352-3018
          Jan 2016
          : 3
          : 1
          Affiliations
          [1 ] Laboratoire de Microbiologie Clinique, Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants Malades, Paris, France; Unité d'Immunologie, Hématologie et Rhumatologie pédiatriques, Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants Malades, Paris, France; EA7327, Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Electronic address: pierre.frange@aphp.fr.
          [2 ] Service de Pédiatrie Générale, Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
          [3 ] Laboratoire de Virologie, Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants Malades, Paris, France; EA7327, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
          [4 ] Service d'Hématologie Pédiatrique, Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Paris, France.
          [5 ] IAME, INSERM UMR1137, Paris, France; Laboratoire de Virologie, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Paris, France.
          [6 ] Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France.
          [7 ] Laboratoire d'Immunologie, Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Paris, France; INSERM UMR1149, Paris, France.
          [8 ] IAME, INSERM UMR1137, Paris, France; Laboratoire de Pharma-Toxicologie, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Paris, France.
          [9 ] Service d'Hématologie et Oncologie pédiatriques, Assistance Publique-Hôpitaux de Paris, Hôpital Trousseau, Paris, France.
          [10 ] INSERM U1018, Université Paris Sud, Le Kremlin Bicêtre, France.
          [11 ] INSERM U1018, Université Paris Sud, Le Kremlin Bicêtre, France; Service d'Epidémiologie et de Santé publique, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Le Kremlin Bicêtre, France.
          [12 ] Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France. Electronic address: asier.saez-cirion@pasteur.fr.
          Article
          S2352-3018(15)00232-5
          10.1016/S2352-3018(15)00232-5
          26762993

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