HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report.

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Abstract

Durable HIV-1 remission after interruption of combined antiretroviral therapy (ART) has been reported in some adults who started treatment during primary infection; however, whether long-term remission in vertically infected children is possible was unknown. We report a case of a young adult perinatally infected with HIV-1 with viral remission despite long-term treatment interruption.

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Journal

Journal ID (iso-abbrev): Lancet HIV

Title: The lancet. HIV

Publisher: Elsevier BV

ISSN (Electronic): 2352-3018

ISSN (Print): 2352-3018

Publication date (Electronic): Jan 2016

Volume: 3

Issue: 1

Affiliations

[1 ] Laboratoire de Microbiologie Clinique, Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants Malades, Paris, France; Unité d'Immunologie, Hématologie et Rhumatologie pédiatriques, Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants Malades, Paris, France; EA7327, Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Electronic address: pierre.frange@aphp.fr.

[2 ] Service de Pédiatrie Générale, Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France.

[3 ] Laboratoire de Virologie, Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants Malades, Paris, France; EA7327, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

[4 ] Service d'Hématologie Pédiatrique, Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Paris, France.

[5 ] IAME, INSERM UMR1137, Paris, France; Laboratoire de Virologie, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Paris, France.

[6 ] Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France.

[7 ] Laboratoire d'Immunologie, Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Paris, France; INSERM UMR1149, Paris, France.

[8 ] IAME, INSERM UMR1137, Paris, France; Laboratoire de Pharma-Toxicologie, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Paris, France.

[9 ] Service d'Hématologie et Oncologie pédiatriques, Assistance Publique-Hôpitaux de Paris, Hôpital Trousseau, Paris, France.

[10 ] INSERM U1018, Université Paris Sud, Le Kremlin Bicêtre, France.

[11 ] INSERM U1018, Université Paris Sud, Le Kremlin Bicêtre, France; Service d'Epidémiologie et de Santé publique, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Le Kremlin Bicêtre, France.

[12 ] Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France. Electronic address: asier.saez-cirion@pasteur.fr.

Article

Publisher Item ID: S2352-3018(15)00232-5

DOI: 10.1016/S2352-3018(15)00232-5

PubMed ID: 26762993

SO-VID: e7798598-cce2-4dae-af35-fc20f1bc0d6e

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