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      Retracted: SPOP Inhibition of Endometrial Carcinoma and Its Clinicopathological Relationship

      retraction
      Applied Bionics and Biomechanics
      Hindawi

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          SPOP Inhibition of Endometrial Carcinoma and Its Clinicopathological Relationship

          Objective Endometrial carcinoma (EC) ranks first in the incidence of female genital malignancies in developed countries. SPOP (speckle-type POZ protein) has changed in EC with a statistically high frequency. This research may play a crucial role in the initiation and progression of EC, ultimately leading to fresh therapeutic targets. Explore the expression of SPOP in EC; observe its effect on the proliferation, invasion, and migration of EC cells after upregulating the expression of SPOP through RNA activation. Methods The expression levels of SPOP protein in 150 EC tissues and 45 normal endometrial tissues were detected by immunohistochemistry and Western blotting. Analyze the relationship between SPOP expression and clinicopathological characteristics. The differences of the proliferation, migration, and invasion abilities between before and after transfection were analyzed using CCK-8 and Transwell assays. Results The results of immunohistochemistry and Western blotting showed the expression level of SPOP in EC tissue significantly reduced or even missed compared with normal endometrial tissue. The results of CCK-8 showed that the growth of EC significantly slowed down after the upregulating of SPOP expression. The results of the Transwell assay showed the migration and invasion abilities of EC cells were weakened after the level of SPOP was upregulated. Conclusions The expression level of SPOP in EC tissues is lower and related to the clinicopathological features compared with normal endometrial tissues. After upregulating the SPOP expression by RNA activation in EC cell lines, the abilities of proliferation, migration, and invasion of cells were significantly inhibited.
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            Author and article information

            Contributors
            Journal
            Appl Bionics Biomech
            Appl Bionics Biomech
            ABB
            Applied Bionics and Biomechanics
            Hindawi
            1176-2322
            1754-2103
            2023
            1 November 2023
            1 November 2023
            : 2023
            : 9895406
            Affiliations
            Article
            10.1155/2023/9895406
            10632042
            e77fb57d-928c-4aee-af2d-b06ab970d360
            Copyright © 2023 Applied Bionics and Biomechanics.

            This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

            History
            : 31 October 2023
            : 31 October 2023
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