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      Linking SLAMF1 to autophagy and sensitivity to therapy in chronic lymphocytic leukemia

      research-article
      a , b , a , b
      Molecular & Cellular Oncology
      Taylor & Francis
      Autophagy, CLL, SLAMF1

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          ABSTRACT

          We recently reported that expression of the costimulatory molecule and microbial sensor SLAMF1 (signaling lymphocytic activation molecule family 1, also known as CD150) is lost in chronic lymphocytic leukemia (CLL) patients characterized by a shorter overall survival. SLAMF1 modulates CLL responses to chemokines and regulates autophagy. Loss of SLAMF1 renders CLL cells relatively unresponsive to autophagy-inducing drugs, including B-cell CLL/lymphoma 2 (BCL2) inhibitors.

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          Author and article information

          Journal
          Mol Cell Oncol
          Mol Cell Oncol
          KMCO
          kmco20
          Molecular & Cellular Oncology
          Taylor & Francis
          2372-3556
          2018
          10 April 2018
          : 5
          : 3
          : e1143077
          Affiliations
          [a ] Department of Medical Sciences, University of Torino , Italy
          [b ] Human Genetics Foundation (HuGeF) , Torino, Italy
          Author notes
          Article
          PMC6149729 PMC6149729 6149729 1143077
          10.1080/23723556.2016.1143077
          6149729
          30250877
          e78ba429-adda-43dd-9acc-46998fc09cd0
          © 2018 Taylor & Francis Group, LLC
          History
          : 7 January 2016
          : 12 January 2016
          : 12 January 2016
          Page count
          Figures: 1, Tables: 0, References: 10, Pages: 3
          Funding
          Funded by: Italian Association for Cancer Research
          Award ID: IG12754
          Funded by: Human Genetics Foundation
          Award ID: HGF001
          Italian Association for Cancer Research (IG12754); Human Genetics Foundation (HGF001).
          Categories
          Author's Views

          SLAMF1,CLL,Autophagy
          SLAMF1, CLL, Autophagy

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