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      Liquid-liquid phase separation in biology.

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          Abstract

          Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that form by phase separation from the cytoplasm. Here we discuss the basic physical concepts necessary to understand the consequences of liquid-like states for biological functions.

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          Author and article information

          Journal
          Annu. Rev. Cell Dev. Biol.
          Annual review of cell and developmental biology
          1530-8995
          1081-0706
          2014
          : 30
          Affiliations
          [1 ] Max Planck Institute of Molecular Cell Biology and Genetics Dresden, and.
          Article
          10.1146/annurev-cellbio-100913-013325
          25288112
          e79a8624-3f2d-4693-bda4-40130b56ef2e
          History

          P granules,biological liquids,chemical potential,origin of life,phase separation

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