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      Measurement of Glomerular Filtration Rate in Man Using DTP A- 99 mTc

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          Abstract

          The aim of this study was the evaluation of the mechanism of renal excretion of DTPA-<sup>99m</sup>Tc in man. For this purpose the renal clearances of DTPA-<sup>99m</sup>Tc and diatrizoate-<sup>131</sup>I were simultaneously determined in 21 patients by means of vesical catheterization and of continuous venous infusion of the tracers. The mean ratio between the clearances of DTPA-<sup>99m</sup>Tc and diatrizoate-<sup>131</sup>I was 0.92 ± (SD) 0.06 (p < 0.001). In order to demonstrate a possible tubular reabsorption of the studied tracer, its clearance was determined simultaneously with those of diatrizoate-<sup>131</sup>I and urea in 10 patients at different urine flow rates, i. e., under basal conditions and at high urine flow induced by hydration. In contrast to the urea clearance, changes in urine flow rate did not significantly affect the clearances of either tracer. In 12 patients the clearance of DTPA-<sup>99m</sup>Tc was also determined by means of external counting over the bladder. The mean ratio between the clearances obtained by external counting and by vesical catheterization was 1.03 ± (SD) 0.05. These results demonstrate that the renal clearance of DTPA-<sup>99m</sup>Tc is slightly lower than the glomerular filtration rate as measured by diatrizoate-<sup>131</sup>I. Since its clearance may be easily measured by means of the noninvasive method of external counting over the bladder, DTPA-<sup>99m</sup>Tc represents a valuable tool in the determination of glomerular filtration rate in man.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1979
          1979
          02 December 2008
          : 24
          : 4
          : 174-178
          Affiliations
          Centro Nefrologico, Clinica Medica Generale II, University of Pisa, Pisa
          Article
          181711 Nephron 1979;24:174–178
          10.1159/000181711
          492428
          © 1979 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          External counting, DTPA-99mTc, GFR, Diatrizoate-131I

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