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      Measurement of Glomerular Filtration Rate in Man Using DTP A- 99 mTc

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          The aim of this study was the evaluation of the mechanism of renal excretion of DTPA-<sup>99m</sup>Tc in man. For this purpose the renal clearances of DTPA-<sup>99m</sup>Tc and diatrizoate-<sup>131</sup>I were simultaneously determined in 21 patients by means of vesical catheterization and of continuous venous infusion of the tracers. The mean ratio between the clearances of DTPA-<sup>99m</sup>Tc and diatrizoate-<sup>131</sup>I was 0.92 ± (SD) 0.06 (p < 0.001). In order to demonstrate a possible tubular reabsorption of the studied tracer, its clearance was determined simultaneously with those of diatrizoate-<sup>131</sup>I and urea in 10 patients at different urine flow rates, i. e., under basal conditions and at high urine flow induced by hydration. In contrast to the urea clearance, changes in urine flow rate did not significantly affect the clearances of either tracer. In 12 patients the clearance of DTPA-<sup>99m</sup>Tc was also determined by means of external counting over the bladder. The mean ratio between the clearances obtained by external counting and by vesical catheterization was 1.03 ± (SD) 0.05. These results demonstrate that the renal clearance of DTPA-<sup>99m</sup>Tc is slightly lower than the glomerular filtration rate as measured by diatrizoate-<sup>131</sup>I. Since its clearance may be easily measured by means of the noninvasive method of external counting over the bladder, DTPA-<sup>99m</sup>Tc represents a valuable tool in the determination of glomerular filtration rate in man.

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          Author and article information

          S. Karger AG
          02 December 2008
          : 24
          : 4
          : 174-178
          Centro Nefrologico, Clinica Medica Generale II, University of Pisa, Pisa
          181711 Nephron 1979;24:174–178
          © 1979 S. Karger AG, Basel

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          Page count
          Pages: 5
          Original Paper

          Cardiovascular Medicine, Nephrology

          External counting, DTPA-99mTc, GFR, Diatrizoate-131I


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