Wei-jie Guan , Ph.D., Zheng-yi Ni , M.D., Yu Hu , M.D., Wen-hua Liang , Ph.D., Chun-quan Ou , Ph.D., Jian-xing He , M.D., Lei Liu , M.D., Hong Shan , M.D., Chun-liang Lei , M.D., David S.C. Hui , M.D., Bin Du , M.D., Lan-juan Li , M.D., Guang Zeng , M.Sc., Kwok-Yung Yuen , Ph.D., Ru-chong Chen , M.D., Chun-li Tang , M.D., Tao Wang , M.D., Ping-yan Chen , M.D., Jie Xiang , M.D., Shi-yue Li , M.D., Jin-lin Wang , M.D., Zi-jing Liang , M.D., Yi-xiang Peng , M.D., Li Wei , M.D., Yong Liu , M.D., Ya-hua Hu , M.D., Peng Peng , M.D., Jian-ming Wang , M.D., Ji-yang Liu , M.D., Zhong Chen , M.D., Gang Li , M.D., Zhi-jian Zheng , M.D., Shao-qin Qiu , M.D., Jie Luo , M.D., Chang-jiang Ye , M.D., Shao-yong Zhu , M.D., Nan-shan Zhong , M.D. *
28 February 2020
Keyword part (code): 18Keyword part (keyword): Infectious DiseaseKeyword part (code): 18_1Keyword part (keyword): Infectious Disease GeneralKeyword part (code): 18_6Keyword part (keyword): Viral InfectionsKeyword part (code): 18_9Keyword part (keyword): Global HealthKeyword part (code): 18_11Keyword part (keyword): Influenza , 18, Infectious Disease, Keyword part (code): 18_1Keyword part (keyword): Infectious Disease GeneralKeyword part (code): 18_6Keyword part (keyword): Viral InfectionsKeyword part (code): 18_9Keyword part (keyword): Global HealthKeyword part (code): 18_11Keyword part (keyword): Influenza , 18_1, Infectious Disease General, 18_6, Viral Infections, 18_9, Global Health, 18_11, Influenza
Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients.
We extracted data regarding 1099 patients with laboratory-confirmed Covid-19 from 552 hospitals in 30 provinces, autonomous regions, and municipalities in mainland China through January 29, 2020. The primary composite end point was admission to an intensive care unit (ICU), the use of mechanical ventilation, or death.
The median age of the patients was 47 years; 41.9% of the patients were female. The primary composite end point occurred in 67 patients (6.1%), including 5.0% who were admitted to the ICU, 2.3% who underwent invasive mechanical ventilation, and 1.4% who died. Only 1.9% of the patients had a history of direct contact with wildlife. Among nonresidents of Wuhan, 72.3% had contact with residents of Wuhan, including 31.3% who had visited the city. The most common symptoms were fever (43.8% on admission and 88.7% during hospitalization) and cough (67.8%). Diarrhea was uncommon (3.8%). The median incubation period was 4 days (interquartile range, 2 to 7). On admission, ground-glass opacity was the most common radiologic finding on chest computed tomography (CT) (56.4%). No radiographic or CT abnormality was found in 157 of 877 patients (17.9%) with nonsevere disease and in 5 of 173 patients (2.9%) with severe disease. Lymphocytopenia was present in 83.2% of the patients on admission.