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      ON THE PRESERVATION OF TYPHUS FEVER RICKETTSIAE IN CULTURES

      The Journal of Experimental Medicine

      The Rockefeller University Press

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          Abstract

          1. Cultures of typhus fever rickettsiae were as a rule found to remain viable and virulent after being stored at 37° and –20°C. for several months, whereas they failed to survive when stored at the intermediate temperatures of 20° and –4°C. for 4 weeks and 10 days respectively. In one instance cultures were stored at 37°C. for 8 months without having been transferred, and were subsequently found to be viable and infectious. 2. The conditions influencing such long survival of an organism which seems to require living tissue for multiplication (as filterable viruses do in general) are discussed. 3. Typhus-infected tissues (minced guinea pig tunica) suspended in a serum-Tyrode mixture in sealed flasks remained infectious at 37°C. for at least 10 weeks. 4. Additional evidence for the etiological significance of the rickettsiae in typhus fever is obtained from the experiments described.

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          Author and article information

          Journal
          J Exp Med
          The Journal of Experimental Medicine
          The Rockefeller University Press
          0022-1007
          1540-9538
          1 January 1935
          : 61
          : 1
          : 17-26
          Affiliations
          From the Laboratories of The Rockefeller Institute for Medical Research
          Article
          2133200
          19870343
          Copyright © Copyright, 1935, by The Rockefeller Institute for Medical Research New York
          Categories
          Article

          Medicine

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