A comprehensive survey of pathways leading to the generation of α-trifluoromethyl
monocyclic piperidinic derivatives is provided (65 references). These compounds have
been synthesized either from 6-membered rings e.g., pipecolic acid or lactam derivatives
by introduction a trifluoromethyl group, from pyridine or pyridinone derivatives by
reduction, and from 5-membered rings e.g., prolinol derivatives by ring expansion,
from linear amines by cyclization or from dienes/dienophiles by [4 + 2]-cycloaddition.