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Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives

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      Abstract

      A comprehensive survey of pathways leading to the generation of α-trifluoromethyl monocyclic piperidinic derivatives is provided (65 references). These compounds have been synthesized either from 6-membered rings e.g., pipecolic acid or lactam derivatives by introduction a trifluoromethyl group, from pyridine or pyridinone derivatives by reduction, and from 5-membered rings e.g., prolinol derivatives by ring expansion, from linear amines by cyclization or from dienes/dienophiles by [4 + 2]-cycloaddition.

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      Most cited references 66

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      Olefin Metathesis in Organic Chemistry

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        Ring-Closing Metathesis and Related Processes in Organic Synthesis

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          Recent Advances in the Total Synthesis of Piperidine and Pyrrolidine Natural Alkaloids with Ring-Closing Metathesis as a Key Step

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            Author and article information

            Affiliations
            Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI), CNRS UMR 8231, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75231 Paris CEDEX 05, France; sarah.rioton@ 123456espci.fr (S.R.); domingo.gomez-pardo@ 123456espci.fr (D.G.P.)
            Author notes
            [* ]Correspondence: Janine.cossy@ 123456espci.fr ; Tel.: +33-140-794-429; Fax: +33-140-794-660
            Contributors
            Role: Academic Editor
            Journal
            Molecules
            Molecules
            molecules
            Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
            MDPI
            1420-3049
            19 March 2017
            March 2017
            : 22
            : 3
            28335499 6155269 10.3390/molecules22030483 molecules-22-00483
            © 2017 by the authors.

            Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

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