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      Cigarette smoking is associated with abnormal histone-to-protamine transition in human sperm.

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          Abstract

          To investigate the association between smoking, semen quality, and the histone-to-protamine transition ratio in mature sperm.

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          Author and article information

          Journal
          Fertil. Steril.
          Fertility and sterility
          1556-5653
          0015-0282
          Jan 2014
          : 101
          : 1
          Affiliations
          [1 ] Key Laboratory for Major Obstetric Diseases of Guangdong Province, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou; Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.
          [2 ] Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou; Key Laboratory of Tropical Diseases Control of Ministry of Education, Sun Yat-sen University, Guangzhou, People's Republic of China.
          [3 ] Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou.
          [4 ] Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou; Key Laboratory of Tropical Diseases Control of Ministry of Education, Sun Yat-sen University, Guangzhou, People's Republic of China. Electronic address: hzhaof@mail.sysu.edu.cn.
          Article
          S0015-0282(13)03050-1
          10.1016/j.fertnstert.2013.09.001
          24112532
          e7f3b8d6-d7cd-412f-93ea-3f22dc3f1adf
          Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
          History

          Smoking,defective spermatogenesis,histone replacement,protamine

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